Acute Myeloid Leukemia with CEBPA Mutation — Variants & evidence

Acute Myeloid Leukemia with CEBPA Mutation — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CEBPA Mutation5
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12173 In this 2022 study, the authors highlighted the diagnostic significance of different types of CEBPA mutations in 4,708 adult AML patients, recruited into the Study Alliance Leukemia trials and spannin… (full text at CIViC) PMID 34320176 · Taube et al., 2022 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12174 In this 2022 study, the authors investigated the diagnostic significance of CEBPA mutations in AML, focusing on data from a large cohort of 1,028 patients aged 70 years or younger from the Japanese Mu… (full text at CIViC) PMID 34448807 · Wakita et al., 2022 · Open in CIViC	civic
(prognostic)	Prognostic	B	Supports Better Outcome	4	accepted	EID12231 In this 2021 study, the authors examined the prognostic implications of CEBPA mutations in pediatric and young adult acute myeloid leukemia (AML) by analyzing 2958 patients enrolled in Children’s Onco… (full text at CIViC) PMID 33951732 · Tarlock et al., 2021 · Open in CIViC	civic
(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12172 In this 2021 study, the authors investigated the role of CEBPA mutations in the diagnosis and prognosis of pediatric and young adult acute myeloid leukemia (AML) in 2958 patients enrolled in Children… (full text at CIViC) PMID 33951732 · Tarlock et al., 2021 · Open in CIViC	civic
〃	Diagnostic	D	Supports Positive	3	accepted	EID12200 In this 2019 study, the authors investigated the diagnostic significance of CEBPA mutations in AML by analyzing how the order of these mutations influences disease development in a mouse model that re… (full text at CIViC) PMID 31784538 · Braun et al., 2019 · Open in CIViC	civic

Data updated 1 hour agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.