Gene
AKT3
AKT serine/threonine kinase 3
Explore in graph →CI-GENE-00000868HGNC:393 ENSG00000117020 NCBI 10000 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (5)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24265155
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AKT3 E17K1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Resistance | 3 | accepted | EID4521An in vitro study of M229 (a human melanoma cell line) endogenously expressing wildtype AKT3 and BRAF V600E (a known BRAF inhibitor sensitizing mutation) found that cells virally induced to stably ove… (full text at CIViC) PMID 24265155 · Shi et al., 2014 · Open in CIViC | civic |
| AKT3 Overexpression4 | ||||||||
| Akt Inhibitor MK2206 | Malignant Breast Neoplasm | Predictive | D | Supports Resistance | 4 | accepted | EID1922Upregulation of AKT3 due to epigenetic reprogramming may confer acquired resistance to AKT inhibitor (MK2206) in breast cancer preclinical model. PMID 27297869 · Stottrup et al., 2016 · | |
Cohorts
Alteration frequency by cohort (56)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 39214094
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Pancreatic Cancer (MSK, Cancer Cell 2024) pancreas_msk_2024 | unmapped | Ssm | 2 | 395 |
Literature
Linked publications (3)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)