Publication
Targeting Akt3 signaling in triple-negative breast cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerTriple-Negative Breast Carcinomacivic_curation1.00
- drugPan-AKT Kinase Inhibitor GSK690693civic_curation1.00
- geneAKT3civic_curation1.00
- variantAKT3 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24335962
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| AKT3 Overexpression2 | ||||||||
| Pan-AKT Kinase Inhibitor GSK690693 | Malignant Breast Neoplasm | Predictive | D | Supports Resistance | 3 | submitted | EID3001Overexpression of AKT3 in lumenal breast cancer cell line SKBR3, which does not express the AKT3 isoform, induced a statistically significant 2.7 fold increase in IC50 for pan-AKT inhibitor GSK690693.… (full text at CIViC) PMID 24335962 · Chin et al., 2014 · Open in CIViC | civic |
| 〃 | Triple-Negative Breast CarcinomaALIAS | Predictive | E | Supports Sensitivity Response | 4 | accepted | EID1923AKT3 was found to be preferentially required for the proliferation and tumor growth of TNBC. It was found to be upregulated in a set of TNBC cell lines compared to other breast cancer types. Depletion… (full text at CIViC) PMID 24335962 · Chin et al., 2014 · Open in CIViC | civic |