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CancerIndexthe global index of cancer

Cancers Data Trials Drugs Genes Biomarkers Approvals Rankings Research gap Graph

Cancers Data Trials Drugs Genes Biomarkers Approvals Rankings Research gap Graph

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CancerIndex

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Neoplasm of Uncertain Histogenesis — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Neoplasm of Uncertain Histogenesis

Cancer

Neoplasm of Uncertain Histogenesis

CI-CAN-00000034Explore in graph →

Non-malignant20,280 active trials259 approved drugs3,813 evidence items

NCIt: C6974
OncoTree: MBT
UMLS CUI: C1334936

Overview
Statistics
Survival
Genomics465
Variants & evidence3813
Drugs427
Trials91351
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (4,399)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 3,901–3,925 of 4,399 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
· Nature · 2012 · PMID 22425996 · validated civic_curation pubmed
Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
· Cancer Discov · 2016 · PMID 26739882 · validated civic_curation pubmed
CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
· PLoS One · 2016 · PMID 26881434 · validated civic_curation pubmed
Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis.
· Genet Mol Res · 2015 · PMID 26662432 · validated civic_curation pubmed
Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.
· Oncotarget · 2015 · PMID 25504439 · validated civic_curation pubmed
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
· Clin Cancer Res · 2012 · PMID 22038994 · validated civic_curation pubmed
Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations.
· Cancer Biol Ther · 2016 · PMID 26574622 · validated civic_curation pubmed

Showing 3,901–3,925 of 4,399 publications

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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma.

· Clin Cancer Res · 2015 · PMID 26179511 · validated civic_curation pubmed

Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.

· Proc Natl Acad Sci U S A · 2015 · PMID 26372962 · validated civic_curation pubmed

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.

· Proc Natl Acad Sci U S A · 2015 · PMID 25733882 · validated civic_curation pubmed

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

· Cancer Discov · 2016 · PMID 26732095 · validated civic_curation pubmed

In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.

· Clin Cancer Res · 2005 · PMID 16243825 · validated civic_curation pubmed

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.

· Cancer Res · 2008 · PMID 18757403 · validated civic_curation pubmed

Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis.

· Sci Rep · 2016 · PMID 26786851 · validated civic_curation pubmed

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice.

· Oncotarget · 2016 · PMID 27049722 · validated civic_curation pubmed

Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK.

· Cancer Med · 2015 · PMID 25727400 · validated civic_curation pubmed

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

· Cancer Discov · 2013 · PMID 23619167 · validated civic_curation pubmed

PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.

· Anticancer Res · 2013 · PMID 23898052 · validated civic_curation pubmed

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.

· Pigment Cell Melanoma Res · 2014 · PMID 24495407 · validated civic_curation pubmed

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.

· Clin Cancer Res · 2011 · PMID 21278246 · validated civic_curation pubmed

The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

· Genes Dev · 2012 · PMID 22802530 · validated civic_curation pubmed

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

· Nature · 2012 · PMID 22281684 · validated civic_curation pubmed

Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.

· Clin Cancer Res · 2013 · PMID 23549875 · validated civic_curation pubmed

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

· Cancer Cell · 2004 · PMID 15324695 · validated civic_curation pubmed

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

· Clin Cancer Res · 2016 · PMID 26589432 · validated civic_curation pubmed