Publication
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (10)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 10
- cancerMalignant Pancreatic Neoplasmcivic_curation1.00
- drugChlorambucilcivic_curation1.00
- drugCisplatincivic_curation1.00
- drugGemcitabinecivic_curation1.00
- drugMelphalancivic_curation1.00
- drugMitomycincivic_curation1.00
- geneBRCA2civic_curation1.00
- geneFANCCcivic_curation1.00
- variantBRCA2 Loss-of-functioncivic_curation1.00
- variantFANCC Loss-of-functioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16243825
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRCA2 Loss-of-function1 | ||||||||
| Mitomycin | Malignant Pancreatic Neoplasm | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1308In pancreatic cell lines PL11 (FANCC-deficient) and CAPAN1 (BRCA2-mutated), sensitivity to DNA cross-linking agents was observed compared to FANCC/BRCA2 wildtype cell lines (Su86.86, CFPAC, AsPc1, and… (full text at CIViC) PMID 16243825 · van der Heijden et al., 2005 · Open in CIViC | civic |
| FANCC Loss-of-function1 | ||||||||
| Chlorambucil + Cisplatin + Gemcitabine + Melphalan + MitomycinSubstitutes | Malignant Pancreatic Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1307In the pancreatic cell lines PL11 (FANCC homozygous deletion) and Hs766T (FANCG-mutated), sensitivity to DNA cross-linking agents was observed. PL11 cells (empty vector transduced) were more sensitive… (full text at CIViC) PMID 16243825 · van der Heijden et al., 2005 · Open in CIViC | civic |