Publication
Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Ovarian Neoplasmcivic_curation1.00
- drugPalbociclibcivic_curation1.00
- geneCCND1civic_curation1.00
- geneCDKN2Acivic_curation1.00
- variantCCND1 Amplificationcivic_curation1.00
- variantCDKN2A Losscivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21278246
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CCND1 Amplification1 | ||||||||
| Palbociclib | Malignant Ovarian Neoplasm | Predictive | D | Does Not Support Sensitivity Response | 3 | accepted | EID1599A panel of 40 ovarian cancer cell lines with varied mutation profiles was assayed for sensitivity to the cdk4/6 inhibitor palbociclib (PD0332991) via measurement of IC50 values for inhibition of proli… (full text at CIViC) PMID 21278246 · Konecny et al., 2011 · Open in CIViC | civic |
| CDKN2A Loss1 | ||||||||
| Palbociclib | Malignant Ovarian Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1377Preclinical study of the effects of PD-0332991 on proliferation, cell-cycle, apoptosis, and Rb phosphorylation in a panel of 40 human ovarian cancer cell lines. Concentration-dependent antiproliferati… (full text at CIViC) PMID 21278246 · Konecny et al., 2011 · Open in CIViC | civic |