Publication
Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMalignant Neoplasmcivic_curation1.00
- drugPan-RAF Inhibitor LY3009120civic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF L485_P490delcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26732095
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF Asn486_Pro490del2 | ||||||||
| (oncogenic) | Malignant NeoplasmALIAS | Oncogenic | D | Supports Oncogenicity | 5 | submitted | EID12993BRAF p.Asn486_Pro490del (NM_004333.6:c.1457_1471del15) causes increased colony formation (triplicates). Class 2 BRAF variant. PMID 26732095 · Chen et al., 2016 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 5 | submitted | EID12994BRAF p.Asn486_Pro490del (NM_004333.6:c.1457_1471del15) causes increased ratio of pERK/ERK. Class 2 BRAF variant. PMID 26732095 · Chen et al., 2016 · Open in CIViC | civic |
| BRAF L485_P490del1 | ||||||||
| Pan-RAF Inhibitor LY3009120 | Malignant NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1267Cells harboring in-frame deletions in BRAF in the L485-P490 amino acid region were found to be sensitive to the RAF dimer inhibitor LY3009120, but not sensitive to the BRAF-selective inhibitors vemura… (full text at CIViC) PMID 26732095 · Chen et al., 2016 · Open in CIViC | civic |