Publication

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

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Cancer Discov2013PMID 23619167PMC3710532stubpubmedPublished

Abstract

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Linked entities

Linked entities (6)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 6

cancerMalignant Head and Neck Neoplasmcivic_curation1.00
drugCetuximabcivic_curation1.00
drugDactolisibcivic_curation1.00
genePIK3CAcivic_curation1.00
variantPIK3CA H1047Rcivic_curation1.00
variantPIK3CA Mutationcivic_curation1.00

Curated evidence

Evidence citing this paper (7)

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PIK3CA C971R1
(oncogenic)	Malignant Head and Neck NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	3	submitted	EID7549 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.C971R. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
PIK3CA G363A2
(oncogenic)	Malignant Head and Neck NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	3	submitted	EID7548 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.G363A. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID10737 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.G363A. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
PIK3CA H1047R2
Cetuximab + DactolisibCombination	Malignant Head and Neck NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	2	accepted	EID1363 Xenografts from one head and neck cancer cell line (CAL-33) with a PIK3CA H1047R mutation were more sensitive to the combined inhibition of PI3K/mTOR and EGFR with BEZ-235 and cetuximab (N=9) than cet… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
Dactolisib	Malignant Head and Neck NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	2	accepted	EID1362 Two head and neck cancer cell lines with PIK3CA H1047R mutation were more sensitive to PI3K/mTOR inhibition with BEZ-235 (NVP-BEZ235, Dactolisib) than two wild type cell lines in vitro. One cell line … (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
PIK3CA Mutation1
Dactolisib	Malignant Head and Neck NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	accepted	EID1360 Preclinical analysis of the predicitive value of PIK3CA mutations for mTOR/PI3K Inhibition with BEZ-235. Two cell lines with PIK3CA Mutation (H1047R) were more sensitive to BEZ-235 than two cell lines… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic
PIK3CA R975S1
(oncogenic)	Malignant Head and Neck NeoplasmALIAS	Oncogenic	D	Supports Oncogenicity	3	submitted	EID7550 Whole-exome sequencing of 151 HNSCC tumours found a high frequency of mutations in PI3K pathway genes. Four novel mutation were found, including PIK3CA p.R975S. Stable transformation of HNSCC cell lin… (full text at CIViC) PMID 23619167 · Lui et al., 2013 · Open in CIViC	civic