Publication
Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
Authors not recorded
Clin Cancer Res2012PMID 22038994PMC3261307stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerUveal Melanomacivic_curation1.00
- drugPanobinostatcivic_curation1.00
- drugTrichostatin Acivic_curation1.00
- drugValproic Acidcivic_curation1.00
- drugVorinostatcivic_curation1.00
- geneBAP1civic_curation1.00
- variantBAP1 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22038994
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BAP1 Mutation1 | ||||||||
| Panobinostat + Trichostatin A + Valproic Acid + VorinostatSubstitutes | Uveal Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1234Somatic and germline BAP1 mutations are associated with uveal melanoma. In this preclinical study, gene set enrichment analysis revealed HDAC inhibitors as potential drugs in BAP1 mutant uveal melanom… (full text at CIViC) PMID 22038994 · Landreville et al., 2012 · Open in CIViC | civic |