Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level388 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,551 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07595107 | Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer | not yet recruiting | — | 180 | Shandong Cancer Hospital and InstituteOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT07596732 | Statewide Unified Network for Remote Intervention of Strength and Exercise(SUNRISE) | not yet recruiting | N/A | 120 | AdventHealth Translational Research InstituteOTHER | 0 |
| May 19, 2026 |
| clinicaltrials |
| NCT07581626 | Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 60 | Chinese PLA General HospitalOTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT05877352 | Intraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial(ELECTRA) | active not recruiting | N/A | 31 | University Hospital Southampton NHS Foundation TrustOTHER | 1 | May 14, 2026 | clinicaltrials |
| NCT06673329 | Brodalumab in the Treatment of Immune-Related Adverse Events | recruiting | Phase 1 | 11 | Brian Henick, MDOTHER | 1 | May 13, 2026 | clinicaltrials |
| NCT05672524 | A Study of Tucatinib and Trastuzumab in People With Rectal Cancer | recruiting | Phase 2 | 37 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT06123156 | Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer(RECTIL) | recruiting | Phase 3 | 188 | University Hospital, RouenOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT07580027 | Preoperative, Adaptive Radiotherapy Concomitant to Chemotherapy for Rectal Adenocarcinoma (Adaptive Rectal Cancer Trial 02) | not yet recruiting | N/A | 33 | IRCCS San RaffaeleOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT06758830 | Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. | recruiting | Phase 2 / Phase 3 | 400 | National Cancer Center Affiliate of Vilnius University Hospital Santaros KlinikosOTHER | 1 | May 11, 2026 | clinicaltrials |
| NCT07253298 | The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer(BFT in LARS) | enrolling by invitation | N/A | 66 | National Taiwan University HospitalOTHER | 1 | May 11, 2026 | clinicaltrials |
| NCT04713618 | Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy(GEORGIA) | active not recruiting | — | 72 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | May 7, 2026 | clinicaltrials |
| NCT03874559 | Exosomes in Rectal Cancer | recruiting | — | 30 | University of Kansas Medical CenterOTHER | 1 | May 6, 2026 | clinicaltrials |
| NCT06239194 | Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors | recruiting | Phase 1 / Phase 2 | 285 | ModeX Therapeutics, An OPKO Health CompanyINDUSTRY | 1 | May 6, 2026 | clinicaltrials |
| NCT06936774 | Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance(iRECOVER) | recruiting | Phase 3 | 140 | University Hospital, Basel, SwitzerlandOTHER | 1 | May 6, 2026 | clinicaltrials |
| NCT06249672 | Longterm Functional Outcomes in Patients Undergoing Organ Preserving Treatment for Rectal Cancer With or Without Local Excision After Chemoradiotherapy(PRESERVE) | recruiting | — | 200 | Insel Gruppe AG, University Hospital BernOTHER | 1 | May 5, 2026 | clinicaltrials |
| NCT07454720 | A Clinical Study of Adebrelimab in Combination With SHR-8068 and Chemoradiotherapy as Perioperative Therapy for Locally Advanced Rectal Cancer | recruiting | Phase 2 / Phase 3 | 165 | Suzhou Suncadia Biopharmaceuticals Co., Ltd.INDUSTRY | 1 | May 5, 2026 | clinicaltrials |
| NCT07566559 | Rectal Cancer Neoadjuvant Therapy-Real World Study(RC-NAT-RWS) | recruiting | — | 869 | Beijing Friendship HospitalOTHER | 1 | May 5, 2026 | clinicaltrials |
| NCT07552207 | Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer(PKUCH-R12) | not yet recruiting | N/A | 30 | Peking University Cancer Hospital & InstituteOTHER | 0 | May 4, 2026 | clinicaltrials |
| NCT07563907 | Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed by Local Excision at Stage I Rectal Cancer(OPTION) | not yet recruiting | N/A | 292 | Seoul National University HospitalOTHER | 1 | May 4, 2026 | clinicaltrials |
| NCT01558921 | Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial(RAPIDO) | active not recruiting | Phase 3 | 920 | University Medical Center GroningenOTHER | 7 | May 1, 2026 | clinicaltrials |
| NCT06729645 | External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer(ACO/ARO/AIO-22) | not yet recruiting | N/A | 80 | University Hospital of CologneOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT07561060 | Low Rectal Cancer Treated With Total Neoadjuvant Therapy Plus Concurrent Tislelizumab Immunotherapy(TNTIT) | recruiting | Phase 1 / Phase 2 | 50 | Fudan UniversityOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT07499921 | Clinical and BIOgical Analyses of RECtal Tumors(BIOREC) | not yet recruiting | N/A | 300 | Centre Leon BerardOTHER | 1 | Apr 30, 2026 | clinicaltrials |
| NCT07528209 | Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer | recruiting | Phase 3 | 556 | Sun Yat-sen UniversityOTHER | 1 | Apr 30, 2026 | clinicaltrials |
| NCT04084249 | ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial | active not recruiting | N/A | 359 | Claus Lindbjerg AndersenOTHER | 1 | Apr 29, 2026 | clinicaltrials |
| NCT06850090 | Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial | recruiting | Phase 3 | 210 | Shandong Cancer Hospital and InstituteOTHER | 1 | Apr 28, 2026 | clinicaltrials |
| NCT04643041 | Watch and Wait in PD-1 Monoclonal Antibody Treated dMMR/MSI-H Distal Rectal Cancer(BASKET) | recruiting | N/A | 47 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 1 | Apr 27, 2026 | clinicaltrials |
| NCT06204094 | Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer(CASINOs) | recruiting | Phase 2 | 37 | Jinhua Central HospitalOTHER | 1 | Apr 24, 2026 | clinicaltrials |
| NCT07551479 | SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer(TORCH-STAR) | not yet recruiting | Phase 3 | 612 | Fudan UniversityOTHER | 1 | Apr 24, 2026 | clinicaltrials |
| NCT05523245 | Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Platform Based on Multi-parametric MRI(DLARC) | recruiting | — | 1,700 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 1 | Apr 23, 2026 | clinicaltrials |
| NCT07381322 | A Study on the Accurate Evaluation of Pseudoprogression of Rectal Cancer Immunotherapy Based on Multitemporal and Multiparameter MRI | recruiting | — | 300 | Peiyi XieOTHER | 1 | Apr 23, 2026 | clinicaltrials |
| NCT06965166 | Contrast-Enhanced Photon-Counting Detector CT (PCD-CT) for the Local Staging of Rectal Cancer | recruiting | — | 200 | Mayo ClinicOTHER | 1 | Apr 22, 2026 | clinicaltrials |
| NCT07543848 | A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer | not yet recruiting | Phase 2 | 20 | Chongqing University Cancer HospitalOTHER | 1 | Apr 22, 2026 | clinicaltrials |
| NCT04544046 | Supportive Oncology Care At Home RCT | active not recruiting | N/A | 300 | Massachusetts General HospitalOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT06424522 | A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients | recruiting | N/A | 80 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT07393048 | Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer(ctDNA-MRD-RC) | recruiting | — | 60 | Beijing Friendship HospitalOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT07407647 | Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer | recruiting | Phase 2 | 25 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT07405476 | Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment | recruiting | Phase 2 | 38 | Emory UniversityOTHER | 1 | Apr 17, 2026 | clinicaltrials |
| NCT07536321 | Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma. | not yet recruiting | — | 46 | Assiut UniversityOTHER | 0 | Apr 17, 2026 | clinicaltrials |
| NCT07537998 | Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial. | recruiting | Phase 2 / Phase 3 | 160 | Pei-Rong DingOTHER | 1 | Apr 17, 2026 | clinicaltrials |
| NCT02863107 | Young-Onset Colorectal Cancer | active not recruiting | — | 818 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT06569368 | Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy | recruiting | Phase 2 | 60 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT03144765 | Multicenter Phase II Study of Transanal TME (taTME) | active not recruiting | N/A | 100 | Icahn School of Medicine at Mount SinaiOTHER | 2 | Apr 15, 2026 | clinicaltrials |
| NCT06274190 | Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary(Treatable) | recruiting | N/A | 158 | KU LeuvenOTHER | 1 | Apr 15, 2026 | clinicaltrials |
| NCT07527026 | A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neoadjuvant Therapy in Locally Advanced Low pMMR/MSS Rectal Cancer | recruiting | Phase 2 | 44 | Chinese PLA General HospitalOTHER | 1 | Apr 14, 2026 | clinicaltrials |
| NCT07527520 | Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial | not yet recruiting | Phase 2 | 165 | Fudan UniversityOTHER | 1 | Apr 14, 2026 | clinicaltrials |
| NCT02688712 | ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer | active not recruiting | Phase 2 | 50 | Providence Health & ServicesOTHER | 1 | Apr 13, 2026 | clinicaltrials |
| NCT06837831 | Mepilex Lite Dressings for the Treatment of Acute Radiation Dermatitis of Anal Canal Skin | recruiting | N/A | 274 | Qianfoshan HospitalOTHER | 1 | Apr 13, 2026 | clinicaltrials |
Data updated 22 days agoSource updated May 19, 2026source: clinicaltrials