Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level388 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,551 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06380101 | Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)(NEAAR-LARC) | recruiting | N/A | 30 | University of South FloridaOTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT03628248 | Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery(AMIREMBOL) | completed | N/A | 10 | Centre Hospitalier Universitaire de Nīmes |
| 1 |
| Dec 4, 2025 |
| clinicaltrials |
| NCT06236633 | Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum(AMIREMBOL_2) | recruiting | N/A | 30 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT07258797 | Short Course or Long Course Radiotherapy as Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer(SHOOL) | not yet recruiting | N/A | 150 | Rajiv Gandhi Cancer Institute & Research Center, IndiaOTHER | 1 | Dec 2, 2025 | clinicaltrials |
| NCT07241143 | Extra-Peritoneal Tunneling Versus Conventional Drain Fixation After Anterior or Low Anterior Resection(ExPeTuD) | not yet recruiting | N/A | 596 | Yeungnam University HospitalOTHER | 1 | Nov 21, 2025 | clinicaltrials |
| NCT01347697 | Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer(NEAPE) | completed | N/A | 91 | Umeå UniversityOTHER | 2 | Oct 3, 2025 | clinicaltrials |
| NCT04827732 | Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in Recurrent Rectal Cancer(IMPARC) | terminated | N/A | 15 | Washington University School of MedicineOTHER | 1 | Sep 29, 2025 | clinicaltrials |
| NCT01843218 | Erectile Rating During the Treatment of Rectal Cancers Localized(METEORR) | completed | N/A | 12 | Institut BergoniéOTHER | 1 | Sep 23, 2025 | clinicaltrials |
| NCT03975491 | The Exercise And Colorectal Cancer Treatment Trial(EXACT) | active not recruiting | N/A | 60 | Pennington Biomedical Research CenterOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT01552226 | Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery | completed | N/A | 98 | Trinity Health MichiganOTHER | 1 | Sep 15, 2025 | clinicaltrials |
| NCT05938322 | Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers(KOMPARC) | recruiting | N/A | 194 | Fondazione Policlinico Universitario Agostino Gemelli IRCCSOTHER | 1 | Sep 5, 2025 | clinicaltrials |
| NCT06217016 | Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2) | withdrawn | N/A | 0 | The First Hospital of Jilin UniversityOTHER | 1 | Aug 28, 2025 | clinicaltrials |
| NCT07137000 | The Effect of Art Therapy in Patients Undergoing Colorectal Cancer | active not recruiting | N/A | 96 | Saglik Bilimleri UniversitesiOTHER | 1 | Aug 22, 2025 | clinicaltrials |
| NCT07134296 | Magnetic Resonance Imaging (MRI)-Guided Rectal Cancer Preservation Program | not yet recruiting | N/A | 32 | Clinica Universidad de Navarra, Universidad de NavarraOTHER | 0 | Aug 21, 2025 | clinicaltrials |
| NCT06087718 | Feasibility of the Maastro Applicator in Rectal Cancer | active not recruiting | N/A | 10 | Maastricht Radiation OncologyOTHER | 1 | Aug 14, 2025 | clinicaltrials |
| NCT07080411 | the Efficacy of MR-guided Online Adaptive Radiotherapy for Locally Advanced Rectal Cancer | not yet recruiting | N/A | 49 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 0 | Jul 23, 2025 | clinicaltrials |
| NCT05010850 | SafeHeal Colovac Colorectal Anastomosis Protection Device Evaluation (SAFE-2) Pivotal Study(SAFE-2) | terminated | N/A | 18 | SafeHeal IncINDUSTRY | 3 | Jul 3, 2025 | clinicaltrials |
| NCT07035600 | Walking and Sitting Difficulties After Rectal Cancer Surgery(WASA) | not yet recruiting | N/A | 300 | Sahlgrenska University HospitalOTHER | 1 | Jun 25, 2025 | clinicaltrials |
| NCT06209099 | Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal Cancer | recruiting | N/A | 96 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jun 12, 2025 | clinicaltrials |
| NCT06761287 | Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer(OPAL) | recruiting | N/A | 20 | Centre Hospitalier Universitaire Saint PierreOTHER | 1 | May 30, 2025 | clinicaltrials |
| NCT05667181 | The Application Value of da Vinci Linear Cutting Stapler SureForm in Robotic Anus Preserving Surgery for Rectal Cancer | completed | N/A | 276 | Nanchang UniversityOTHER | 1 | May 28, 2025 | clinicaltrials |
| NCT06214988 | Selective Defunctioning Stoma in Low Anterior Resection for Rectal Cancer(SELSA) | recruiting | N/A | 212 | Skane University HospitalOTHER | 1 | May 21, 2025 | clinicaltrials |
| NCT05914766 | An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer(PATHWAYS) | recruiting | N/A | 80 | Massachusetts General HospitalOTHER | 1 | May 18, 2025 | clinicaltrials |
| NCT06956976 | Preservation Vs. Dissection of No. 253 Lymph Nodes of Robotic Resection for Mid/Low Rectal Cancer(REAL2) | not yet recruiting | N/A | 1,596 | Fudan UniversityOTHER | 1 | May 4, 2025 | clinicaltrials |
| NCT06943690 | Safety and Efficacy Study of Single-port Robotic Versus Multi-port Robotic Radical Rectal Cancer Surgery | not yet recruiting | N/A | 212 | Ruijin HospitalOTHER | 1 | Apr 24, 2025 | clinicaltrials |
| NCT04441580 | Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting(GENIAL-CO) | completed | N/A | 900 | Fondazione Poliambulanza Istituto OspedalieroOTHER | 1 | Apr 10, 2025 | clinicaltrials |
| NCT06740357 | Implementation of a Tumor Response Assessment Program Integrating the Shared Medical Decision Into the Organ Preservation Strategy for Rectal Cancer Patients(EVAREC) | recruiting | N/A | 270 | Centre Hospitalier Universitaire DijonOTHER | 1 | Apr 9, 2025 | clinicaltrials |
| NCT05390398 | Study on Fatigue in Colorectal Cancer Survivors, a Lifestyle Intervention(SoFiT) | completed | N/A | 161 | Wageningen UniversityOTHER | 1 | Mar 28, 2025 | clinicaltrials |
| NCT06894797 | Preoperative Chemoradiotherapy Combined With Consolidation or Induction NALIRIFOX in Rectal Cancer. | recruiting | N/A | 68 | Peking University Cancer Hospital & InstituteOTHER | 1 | Mar 25, 2025 | clinicaltrials |
| NCT05179837 | Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps | terminated | N/A | 36 | Washington University School of MedicineOTHER | 1 | Mar 19, 2025 | clinicaltrials |
| NCT06854679 | Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy(ANDROMEDA) | recruiting | N/A | 13 | Royal Marsden NHS Foundation TrustOTHER | 1 | Mar 3, 2025 | clinicaltrials |
| NCT01226979 | Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer(HDRBT) | completed | N/A | 16 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Feb 28, 2025 | clinicaltrials |
| NCT06831981 | Hyperthermia With Chemoradiotherapy in Rectal Cancer(ARO 2024-13) | recruiting | N/A | 264 | University Hospital TuebingenOTHER | 1 | Feb 18, 2025 | clinicaltrials |
| NCT04015804 | Robotic Low Rectum Anterior Resection(GROG-R01) | completed | N/A | 833 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 3 | Feb 12, 2025 | clinicaltrials |
| NCT04103567 | Determination of Microbiological Factors Associated With Poor Response to Neoadjuvant Treatment in Rectal Cancers(MICARE) | recruiting | N/A | 220 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 1 | Feb 12, 2025 | clinicaltrials |
| NCT04224779 | Liquid Biopsies and IMAging for Improved Cancer Care(LIMA) | active not recruiting | N/A | 16 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 1 | Feb 12, 2025 | clinicaltrials |
| NCT06805045 | Image-Guided Surgery In The Treatment Of Rectal Cancer (AR_CRC) | recruiting | N/A | 50 | IRCCS Azienda Ospedaliero-Universitaria di BolognaOTHER | 1 | Feb 3, 2025 | clinicaltrials |
| NCT05887531 | Abdominopelvic Cancer Prehabilitation | completed | N/A | 66 | Universitat Jaume IOTHER | 1 | Jan 29, 2025 | clinicaltrials |
| NCT03154190 | Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer | completed | N/A | 128 | Stanford UniversityOTHER | 1 | Jan 24, 2025 | clinicaltrials |
| NCT06730035 | PRediction of Outcomes and PERsonalized Radiotherapy by Biomarkers and Functional Imaging | active not recruiting | N/A | 30 | IRCCS Azienda Ospedaliero-Universitaria di BolognaOTHER | 1 | Dec 12, 2024 | clinicaltrials |
| NCT01461525 | Comparison of Sphincter Preservation Surgery and Abdominoperineal Resection (APR): Prospective Clinical Trial(ASPIRE) | completed | N/A | 342 | Seoul National University HospitalOTHER | 1 | Dec 5, 2024 | clinicaltrials |
| NCT05164315 | Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0 | terminated | N/A | 14 | Seoul National University HospitalOTHER | 1 | Dec 5, 2024 | clinicaltrials |
| NCT03828318 | Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial | completed | N/A | 160 | Jewish General HospitalOTHER | 2 | Nov 29, 2024 | clinicaltrials |
| NCT05000697 | Chemoradiation and Consolidation Chemotherapy With or Without Oxaliplatin for Distal Rectal Cancer and Watch and Wait(CCHOWW) | recruiting | N/A | 216 | Hospital Alemão Oswaldo CruzOTHER | 3 | Nov 27, 2024 | clinicaltrials |
| NCT05461248 | Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer | completed | N/A | 60 | The First Hospital of Jilin UniversityOTHER | 1 | Nov 22, 2024 | clinicaltrials |
| NCT04999007 | Artificial Intelligence Assists Surgeons' Decision Making | recruiting | N/A | 616 | Jichao QinOTHER | 1 | Nov 21, 2024 | clinicaltrials |
| NCT04103372 | Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery(PRESERVE) | recruiting | N/A | 200 | Imperial College LondonOTHER | 1 | Nov 4, 2024 | clinicaltrials |
| NCT05424692 | Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer | recruiting | N/A | 200 | Peking Union Medical College HospitalOTHER | 1 | Nov 4, 2024 | clinicaltrials |
| NCT06662643 | A Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophylactic Ileostomy in the Treatment of Low Rectal Cancer After Internal Sphincter Resection(STAR-TAR) | active not recruiting | N/A | 110 | Zhongnan HospitalOTHER | 1 | Oct 29, 2024 | clinicaltrials |
| NCT06653452 | Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer | recruiting | N/A | 30 | Peking Union Medical College HospitalOTHER | 1 | Oct 22, 2024 | clinicaltrials |
Data updated 23 days agoSource updated Dec 10, 2025source: clinicaltrials