Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer

Inclusion criteria

1. Age: 18\~75 years old, male or female;
2. Pathological diagnosis of adenocarcinoma of the rectum on preoperative biopsy;
3. Clinical staging was T1-4aN0-2M0;
4. No distant multiple metastases;
5. ECOG rating 0-2;
6. Cardiac, pulmonary, hepatic and renal functions met the criteria for surgical tolerance
7. Clinical diagnosis of middle and low rectal cancer, the lower edge of the tumour is within 10cm from the anal verge, and it is proposed to perform radical rectal surgery and prophylactic ileostomy at stage I, and intestinal closure at stage II;
8. Patients and their families were able to understand and willing to participate in this clinical study and signed an informed consent form.

Exclusion criteria

1\. Previous history of malignant colorectal tumour or recently diagnosed combination of other malignant tumours; 2、Patients with combined intestinal obstruction, intestinal perforation, intestinal haemorrhage, etc. requiring emergency surgery; 3. Neighbouring organs requiring combined organ removal; 4. ASA classification ≥ Grade IV and/or ECOG physical status score \> 2; 5. Those who have serious liver and kidney dysfunction, cardiopulmonary dysfunction, coagulation dysfunction or combined serious basic diseases cannot tolerate the surgery; 6. Have a history of serious mental illness; 7. Pregnant or breastfeeding women; 8. Those who have a history of taking steroid drugs; 9. Patients with other clinical and laboratory conditions considered by the investigator to be inappropriate for participation in the trial; 10. One week before the operation, there are signs of infection, body temperature rises \>37.5°C, blood WBC \>10.0×109/L; 11. History of antibiotic use 1 week prior to surgery (excluding preoperative shock medication); 12. Preoperative neoadjuvant patients

Exit criteria

1. Accompanied by other non-oncological conditions that make it impossible for the patient to continue to receive this treatment plan;
2. After enrolment in the study, patients who required emergency surgery due to intestinal obstruction, perforation, or bleeding,et al. prior to stoma closure;
3. Patients with pathologically confirmed distant metastases after rectal surgery, including liver, pelvis, ovary, peritoneum, and distant lymph node metastases;
4. Intraoperative exploration for middle and low rectal cancer in anus-preserving surgery for those who need combined organ resection;
5. After enrolment in the study, patients requested to withdraw from the study cohort for various reasons, or were unable to complete the study programme and follow-up for various reasons;
6. Anastomotic fistula, severe anastomotic stenosis (inability to pass through enteroscopy or oesophageal finger and inability to dilate via oesophageal finger) after radical rectal surgery.