Cancer
Malignant Prostate Neoplasm
CI-CAN-00005927Explore in graph →
Top-level1,375 active trials24 approved drugs58 evidence items
- NCIt
- C7378
- ICD-10
- C61
- DOID
- 10283
- Other
- 2 more codes
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Cancer
CI-CAN-00005927Explore in graph →
Genomics
28 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
2,069 cases with simple somatic mutation data · 2,069 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 551 |
| 2,069 |
| 26.6% |
| cbioportal |
| 2 | FOXA1 | Ssm | 273 | 2,069 | 13.2% | cbioportal |
| 3 | SPOP | Ssm | 260 | 2,069 | 12.6% | cbioportal |
| 4 | PTEN | Ssm | 155 | 2,069 | 7.5% | cbioportal |
| 5 | KMT2C | Ssm | 140 | 2,069 | 6.8% | cbioportal |
| 6 | APC | Ssm | 138 | 2,069 | 6.7% | cbioportal |
| 7 | KMT2D | Ssm | 133 | 2,069 | 6.4% | cbioportal |
| 9 | ZFHX3 | Ssm | 110 | 1,924 | 5.7% | cbioportal |
| 8 | CDK12 | Ssm | 118 | 2,069 | 5.7% | cbioportal |
| 10 | PIK3CA | Ssm | 92 | 2,069 | 4.4% | cbioportal |
| 11 | ATM | Ssm | 86 | 2,069 | 4.2% | cbioportal |
| 12 | AR | Ssm | 80 | 2,069 | 3.9% | cbioportal |
| 13 | CTNNB1 | Ssm | 78 | 2,069 | 3.8% | cbioportal |
| 14 | BRCA2 | Ssm | 74 | 2,069 | 3.6% | cbioportal |
| 15 | SPEN | Ssm | 70 | 2,069 | 3.4% | cbioportal |
| 27 | ERF | Ssm | 47 | 1,402 | 3.4% | cbioportal |
| 16 | KDM6A | Ssm | 69 | 2,069 | 3.3% | cbioportal |
| 20 | MGA | Ssm | 61 | 1,924 | 3.2% | cbioportal |
| 17 | JAK1 | Ssm | 64 | 2,069 | 3.1% | cbioportal |
| 18 | RB1 | Ssm | 63 | 2,069 | 3% | cbioportal |
| 19 | GRIN2A | Ssm | 61 | 2,069 | 2.9% | cbioportal |
| 21 | FAT1 | Ssm | 56 | 2,069 | 2.7% | cbioportal |
| 23 | MED12 | Ssm | 52 | 2,069 | 2.5% | cbioportal |
| 22 | KMT2A | Ssm | 52 | 2,069 | 2.5% | cbioportal |
| 24 | ASXL1 | Ssm | 50 | 2,069 | 2.4% | cbioportal |
| 25 | NCOR1 | Ssm | 50 | 2,069 | 2.4% | cbioportal |
| 26 | PTPRD | Ssm | 49 | 2,069 | 2.4% | cbioportal |
| 44 | KMT2B | Ssm | 32 | 1,402 | 2.3% | cbioportal |
| 28 | ARID1A | Ssm | 43 | 2,069 | 2.1% | cbioportal |
| 29 | PIK3R1 | Ssm | 41 | 2,069 | 2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13