BAP1 Loss

CI-VAR-00002487Explore in graph →CIViC 2212

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 4 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Kidney Carcinoma1
BAP1 Loss	Olaparib	Predictive	D	Supports Sensitivity Response	3	submitted	EID5930 BAP1 loss sensitized cells to the PARP inhibitor olaparib. In addition, BAP1-deficient cells were more sensitive to ionizing radiation. PMID 22683710 · Peña-Llopis et al., 2012 · Open in CIViC	civic
Malignant Mesothelioma1
BAP1 Loss	Mocetinostat + VorinostatSubstitutes	Predictive	E	Supports Sensitivity Response	2	accepted	EID1235 A siRNA screen identified BAP1 associated with HDAC1 and HDAC2 expression. HDAC2 or BAP1 depletion sensitized a mesothelioma cell line (MSTO-211H) to HDAC inhibitors vorinostat or mocetinostat. The pa… (full text at CIViC) PMID 25970771 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Pleural Malignant Mesothelioma1
BAP1 Loss	EPZ011989	Predictive	D	Supports Sensitivity Response	2	submitted	EID8329 The in vivo experiment demonstrated that Bap1 loss results in increased trimethylated histone H3 lysine 27 (H3K27me3), elevated Ezh2 expression, and enhanced repression of Polycomb Repressive Complex … (full text at CIViC) PMID 26437366 · LaFave et al., 2015 · Open in CIViC	civic

Unmapped disease1unmapped disease
BAP1 Loss	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID12007 In this paper, the collateral vulnerabilities that arise as a consequence of the inactivation or loss of function of certain tumour suppressor genes, specifically in malignant pleural mesothelioma (MP… (full text at CIViC) PMID 33072611 · Xu et al., 2020 · Open in CIViC	civic