Variant · Expression
MDM2 EXPRESSION
CI-VAR-00000908Explore in graph →CIViC 343
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32655895
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Ovarian Neoplasm1 | ||||||||
| MDM2 EXPRESSION | Navtemadlin | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID9852In this preclinical study, high MDM2 expressing human ovarian cancer cell lines (OVTOKO and OVMANA) exhibited resistance to t-killing cells with a dead/live ratio of 4.2:1 and 1.9:1; (P = 0.03 and P =… (full text at CIViC) PMID 32655895 · Sahin et al., 2020 · Open in CIViC | civic |
| Pleural Malignant Mesothelioma2 | ||||||||
| MDM2 EXPRESSION | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID82872 patients with malignant pleural mesothelioma were analyzed, MDM2 immunoexpression was assessed in 65 patients. MDM2 mRNA and protein expression correlated with poor OS and PFS for patients treated … (full text at CIViC) PMID · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available