Cancer Family
Malignant Breast Neoplasm
CI-CAN-00000227Explore in graph →
Top-level2,627 active trials43 approved drugs310 evidence items
- NCIt
- C9335
- ICD-10
- C50
- DOID
- 1612
- Other
- 2 more codes
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Cancer Family
CI-CAN-00000227Explore in graph →
Genomics
32 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
3,879 cases with simple somatic mutation data · 3,879 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 1,707 |
| 3,879 |
| 44% |
| cbioportal |
| 2 | PIK3CA | Ssm | 1,401 | 3,879 | 36.1% | cbioportal |
| 3 | GATA3 | Ssm | 582 | 3,879 | 15% | cbioportal |
| 4 | CDH1 | Ssm | 566 | 3,879 | 14.6% | cbioportal |
| 5 | ESR1 | Ssm | 388 | 3,879 | 10% | cbioportal |
| 6 | KMT2C | Ssm | 357 | 3,879 | 9.2% | cbioportal |
| 7 | MAP3K1 | Ssm | 314 | 3,879 | 8.1% | cbioportal |
| 8 | PTEN | Ssm | 303 | 3,879 | 7.8% | cbioportal |
| 9 | ARID1A | Ssm | 279 | 3,879 | 7.2% | cbioportal |
| 10 | TBX3 | Ssm | 237 | 3,879 | 6.1% | cbioportal |
| 11 | AKT1 | Ssm | 220 | 3,879 | 5.7% | cbioportal |
| 12 | NF1 | Ssm | 217 | 3,879 | 5.6% | cbioportal |
| 13 | FOXA1 | Ssm | 194 | 3,879 | 5% | cbioportal |
| 14 | KMT2D | Ssm | 188 | 3,879 | 4.8% | cbioportal |
| 15 | ERBB2 | Ssm | 182 | 3,879 | 4.7% | cbioportal |
| 16 | MAP2K4 | Ssm | 169 | 3,879 | 4.4% | cbioportal |
| 17 | RB1 | Ssm | 169 | 3,879 | 4.4% | cbioportal |
| 18 | NCOR1 | Ssm | 163 | 3,879 | 4.2% | cbioportal |
| 19 | SPEN | Ssm | 157 | 3,879 | 4% | cbioportal |
| 20 | CBFB | Ssm | 153 | 3,879 | 3.9% | cbioportal |
| 21 | BRCA2 | Ssm | 152 | 3,879 | 3.9% | cbioportal |
| 22 | FAT1 | Ssm | 149 | 3,879 | 3.8% | cbioportal |
| 23 | RUNX1 | Ssm | 143 | 3,879 | 3.7% | cbioportal |
| 24 | ATM | Ssm | 126 | 3,879 | 3.2% | cbioportal |
| 25 | KMT2A | Ssm | 122 | 3,879 | 3.1% | cbioportal |
| 26 | ZFHX3 | Ssm | 110 | 3,508 | 3.1% | cbioportal |
| 52 | PREX2 | Ssm | 76 | 2,602 | 2.9% | cbioportal |
| 32 | MGA | Ssm | 99 | 3,508 | 2.8% | cbioportal |
| 27 | PIK3R1 | Ssm | 106 | 3,879 | 2.7% | cbioportal |
| 59 | KMT2B | Ssm | 70 | 2,602 | 2.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-20