Hematologic Malignancy
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene
CI-CAN-00002364Explore in graph →
Hematologic1 active trials
- NCIt
- C37204
Loading cancer entity…
Loading cancer entity…
Hematologic Malignancy
CI-CAN-00002364Explore in graph →
Data completeness1 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Anatomy
Data updated 19 hours agoSource updated unknowncounters aggregate over descendants
Names
CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.
Key figures
Each figure carries its unit, period and source; ranks link to "Why this rank?".
No registry-level ancestor: burden figures are published for the mutually exclusive top-level site groups only, and this entity does not descend from one. Global figures (IARC / GLOBOCAN) stay under license review and SEER awaits credentials.
Data updated 19 hours agoSource updated unknownregistry figures: none · counters aggregate over descendants