Childhood Acute Myeloid Leukemia — Variants & evidence

Childhood Acute Myeloid Leukemia — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

6 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items (5 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
GLIS2 Fusion1
(prognostic)	Childhood Acute Megakaryoblastic Leukemia	Prognostic	B	Supports Poor Outcome	4	submitted	EID8503 Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic
AFDN Fusion1
(prognostic)	Childhood Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	4	submitted	EID8515 This is a large international retrospective study of the association between fusion partner and outcome in 756 children with KMT2A-rearranged (also known as MLL-rearranged) AML from 11 study group inc… (full text at CIViC) PMID 19528532 · Balgobind et al., 2009 · Open in CIViC	civic
MRTFA Fusion4
(diagnostic)	Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1ALIAS	Diagnostic	A	Supports Positive	5	submitted	EID8513 AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1, is a defined diagnostic subgroup in the 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukem… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
〃	Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1ALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12260 In this study, the authors investigated the association of the RBM15::MRTFA fusion with acute megakaryoblastic leukemia (AMKL, FAB-M7), particularly in non-Down syndrome infants and young children. A… (full text at CIViC) PMID 11431691 · Ma et al., 2001 · Open in CIViC	civic
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Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.