GLIS2 Fusion

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Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Megakaryoblastic Leukemia1
CBFA2T3::GLIS2 Fusion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	submitted	EID8551 The authors studied non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL). Transcriptome sequencing was performed on diagnostic blasts from 14 patients. Validation cohort consisted of 34 ped… (full text at CIViC) PMID 23153540 · Gruber et al., 2012 · Open in CIViC	civic
Acute Myeloid Leukemia1
CBFA2T3::GLIS2 Fusion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	submitted	EID7126 Whole transcriptome RNA-seq was performed in pediatric patients with cytogenetically normal acute myeloid leukemia. Identified a recurrent cryptic inversion of chromosome 16, that gives rise to an in… (full text at CIViC) PMID 23407549 ·

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

Acute Megakaryoblastic Leukemia1

CBFA2T3::GLIS2 Fusion

(prognostic)

Prognostic

Supports Poor Outcome

submitted

EID8551

The authors studied non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL). Transcriptome sequencing was performed on diagnostic blasts from 14 patients. Validation cohort consisted of 34 ped… (full text at CIViC)

PMID 23153540 · Gruber et al., 2012 · Open in CIViC

civic

Acute Myeloid Leukemia1

CBFA2T3::GLIS2 Fusion

(prognostic)

Prognostic

Supports Poor Outcome

submitted

EID7126

Whole transcriptome RNA-seq was performed in pediatric patients with cytogenetically normal acute myeloid leukemia. Identified a recurrent cryptic inversion of chromosome 16, that gives rise to an in… (full text at CIViC)

PMID 23407549 ·

Childhood Acute Megakaryoblastic Leukemia1
CBFA2T3::GLIS2 Fusion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	submitted	EID8503 Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic

Childhood Acute Megakaryoblastic Leukemia1

CBFA2T3::GLIS2 Fusion

(prognostic)

Prognostic

Supports Poor Outcome

submitted

EID8503

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC)

PMID 27114462 · de Rooij et al., 2016 · Open in CIViC

civic

Acute Myeloid Leukemia With CBFA2T3::GLIS2 Fusion4unmapped disease
CBFA2T3::GLIS2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11884 In this 2012 study they included 14 patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL), a subtype of pediatric acute myeloid leukemia (AML). Transcriptome sequencing was … (full text at CIViC) PMID 23153540 · Gruber et al., 2012 · Open in CIViC	civic
CBFA2T3::GLIS2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11885 In this 2012 study the authors performed high-throughput sequencing of RNA (RNA-seq) of leukemic cells obtained after engraftment in immunodeficient mice from 5 patients with Acute megakaryoblastic le… (full text at CIViC) PMID 23045605 · Thiollier et al., 2012 · Open in CIViC	civic
CBFA2T3::GLIS2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11886 In this 2017 study the authors included 74 pediatric patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL). RNASeq was performed on 62 patients, where sufficient RNA was ava… (full text at CIViC) PMID 28112737 · de Rooij et al., 2017 · Open in CIViC	civic
CBFA2T3::GLIS2 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID11887 This 2013 study included 7 pediatric acute myeloid leukaemia (AML) patients defined as cytogenetically normal (CN). They performed whole-transcriptome massively parallel sequencing and identified a ch… (full text at CIViC) PMID 23407549 · Masetti et al., 2013 · Open in CIViC	civic

Acute Myeloid Leukemia With CBFA2T3::GLIS2 Fusion4unmapped disease

CBFA2T3::GLIS2 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11884

In this 2012 study they included 14 patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL), a subtype of pediatric acute myeloid leukemia (AML). Transcriptome sequencing was … (full text at CIViC)

PMID 23153540 · Gruber et al., 2012 · Open in CIViC

civic

CBFA2T3::GLIS2 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11885

In this 2012 study the authors performed high-throughput sequencing of RNA (RNA-seq) of leukemic cells obtained after engraftment in immunodeficient mice from 5 patients with Acute megakaryoblastic le… (full text at CIViC)

PMID 23045605 · Thiollier et al., 2012 · Open in CIViC

civic

CBFA2T3::GLIS2 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11886

In this 2017 study the authors included 74 pediatric patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL). RNASeq was performed on 62 patients, where sufficient RNA was ava… (full text at CIViC)

PMID 28112737 · de Rooij et al., 2017 · Open in CIViC

civic

CBFA2T3::GLIS2 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11887

This 2013 study included 7 pediatric acute myeloid leukaemia (AML) patients defined as cytogenetically normal (CN). They performed whole-transcriptome massively parallel sequencing and identified a ch… (full text at CIViC)

PMID 23407549 · Masetti et al., 2013 · Open in CIViC

civic

Evidence by cancer (7 items)

Clinical significance (0)