MRTFA Fusion

CI-VAR-00001296Explore in graph →CIViC 3116

Curated evidence

Evidence by cancer (6 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–6 of 6 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Megakaryoblastic Leukemia2
RBM15::MRTFA Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	4	submitted	EID8512 AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL, is a defined subgroup of AML in the WHO 2016 classification of myeloid neoplasms and acute leukemias. In this manuscript by O'Brien et al, o… (full text at CIViC) PMID 22918081 · O'Brien et al., 2013 · Open in CIViC	civic
RBM15::MRTFA Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	4	submitted	EID8514 In this manuscript, data and clinical samples from 153 newly diagnosed non-Down syndrome pediatric AMKL cases were analyzed. Patients samples were screened for the recurrent molecular aberrations in N… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL14
RBM15::MRTFA Fusion	(diagnostic)	Diagnostic	A	Supports Positive	5	submitted	EID8513 AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1, is a defined diagnostic subgroup in the 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukem… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
RBM15::MRTFA Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12260 In this study, the authors investigated the association of the RBM15::MRTFA fusion with acute megakaryoblastic leukemia (AMKL, FAB-M7), particularly in non-Down syndrome infants and young children. A… (full text at CIViC) PMID 11431691 · Ma et al., 2001 · Open in CIViC	civic
RBM15::MRTFA Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12261 In this study, the authors explored the genomic landscape of acute megakaryoblastic leukemia (AMKL) in patients without Down syndrome (non-DS-AMKL). AMKL is a rare and heterogeneous subtype of acute m… (full text at CIViC) PMID 28112737 · de Rooij et al., 2017 · Open in CIViC	civic
RBM15::MRTFA Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12262 In this study, the authors performed an international retrospective analysis of 490 pediatric patients (≤18 years) with non–Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), a rare and aggr… (full text at CIViC) PMID 26215111 · Inaba et al., 2015 · Open in CIViC	civic