Cervical Neoplasm — Genomics

Cervical Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

7 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma TCGA-CESCTCGA

306 cases with simple somatic mutation data · 307 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA, Firehose Legacy) cesc_tcgaTCGA

194 cases with simple somatic mutation data · 310 cases total · 2026-01-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	62	194	32%	cbioportal
2	PIK3CA	Ssm	53	194	27.3%	cbioportal
3	MUC4	Ssm	37	194	19.1%	cbioportal
4	KMT2C	Ssm	29	194	14.9%	cbioportal
5	MUC16	Ssm	28	194	14.4%	cbioportal
6	ADGRV1	Ssm	26	194	13.4%	cbioportal
7	SYNE1	Ssm	23	194	11.9%	cbioportal
8	KMT2D	Ssm	22	194	11.3%	cbioportal
9	EP300	Ssm	21	194	10.8%	cbioportal
10	RYR2	Ssm	21	194	10.8%	cbioportal
11	DMD	Ssm	20	194	10.3%	cbioportal
12	FLG	Ssm	20	194	10.3%	cbioportal
13	SYNE2	Ssm	20	194	10.3%	cbioportal
14	FBXW7	Ssm	19	194	9.8%	cbioportal
15	USH2A	Ssm	18	194	9.3%	cbioportal
16	OBSCN	Ssm	17	194	8.8%	cbioportal
20	MDN1	Ssm	16	194	8.2%	cbioportal
21	MUC12	Ssm	16	194	8.2%	cbioportal
19	MACF1	Ssm	16	194	8.2%	cbioportal
17	HLA-A	Ssm	16	194	8.2%	cbioportal
18	HMCN1	Ssm	16	194	8.2%	cbioportal
22	MUC5B	Ssm	16	194	8.2%	cbioportal
26	DNAH6	Ssm	15	194	7.7%	cbioportal
27	NEB	Ssm	15	194	7.7%	cbioportal
28	PCLO	Ssm	15	194	7.7%	cbioportal
29	PTEN	Ssm	15	194	7.7%	cbioportal
25	ARID1A	Ssm	15	194	7.7%	cbioportal
24	APOB	Ssm	15	194	7.7%	cbioportal
23	ABCA12	Ssm	15	194	7.7%	cbioportal
30	CREBBP	Ssm	14	194	7.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Cervical Squamous Cell Carcinoma (TCGA GDC, 2025) cesc_tcga_gdcTCGA GDC

289 cases with simple somatic mutation data · 309 cases total · 2026-01-13 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	87	289	30.1%	cbioportal
2	PIK3CA	Ssm	81	289	28%	cbioportal
3	KMT2C	Ssm	54	289	18.7%	cbioportal
4	MUC16	Ssm	49	289	17%	cbioportal
5	KMT2D	Ssm	39	289	13.5%	cbioportal
6	FLG	Ssm	37	289	12.8%	cbioportal
7	EP300	Ssm	36	289	12.5%	cbioportal
9	SYNE1	Ssm	35	289	12.1%	cbioportal
8	DMD	Ssm	35	289	12.1%	cbioportal
10	FBXW7	Ssm	34	289	11.8%	cbioportal
11	LRP1B	Ssm	33	289	11.4%	cbioportal
12	RYR2	Ssm	32	289	11.1%	cbioportal
13	DST	Ssm	31	289	10.7%	cbioportal
15	USH2A	Ssm	29	289	10%	cbioportal
14	ADGRV1	Ssm	29	289	10%	cbioportal
17	MUC17	Ssm	28	289	9.7%	cbioportal
16	HUWE1	Ssm	28	289	9.7%	cbioportal
18	LRP2	Ssm	24	289	8.3%	cbioportal
21	SYNE2	Ssm	24	289	8.3%	cbioportal
19	NAV3	Ssm	24	289	8.3%	cbioportal
20	NEB	Ssm	24	289	8.3%	cbioportal
22	PCLO	Ssm	23	289	8%	cbioportal
26	HMCN1	Ssm	22	289	7.6%	cbioportal
28	MUC5B	Ssm	22	289	7.6%	cbioportal
27	MDN1	Ssm	22	289	7.6%	cbioportal
25	FAT1	Ssm	22	289	7.6%	cbioportal
24	DNAH2	Ssm	22	289	7.6%	cbioportal
23	CREBBP	Ssm	22	289	7.6%	cbioportal
30	HYDIN	Ssm	21	289	7.3%	cbioportal
29	CSMD1	Ssm	21	289	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) cesc_tcga_pan_can_atlas_2018TCGA

291 cases with simple somatic mutation data · 297 cases total · 2026-06-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	91	291	31.3%	cbioportal
2	PIK3CA	Ssm	83	291	28.5%	cbioportal
3	KMT2C	Ssm	54	291	18.6%	cbioportal
4	MUC4	Ssm	50	291	17.2%	cbioportal
5	MUC16	Ssm	48	291	16.5%	cbioportal
6	KMT2D	Ssm	41	291	14.1%	cbioportal
7	FLG	Ssm	38	291	13.1%	cbioportal
8	DMD	Ssm	37	291	12.7%	cbioportal
9	SYNE1	Ssm	37	291	12.7%	cbioportal
10	EP300	Ssm	35	291	12%	cbioportal
11	FBXW7	Ssm	35	291	12%	cbioportal
12	RYR2	Ssm	35	291	12%	cbioportal
14	USH2A	Ssm	33	291	11.3%	cbioportal
13	LRP1B	Ssm	33	291	11.3%	cbioportal
16	MUC17	Ssm	30	291	10.3%	cbioportal
15	ADGRV1	Ssm	30	291	10.3%	cbioportal
17	HUWE1	Ssm	28	291	9.6%	cbioportal
18	CSMD1	Ssm	27	291	9.3%	cbioportal
19	NEB	Ssm	26	291	8.9%	cbioportal
20	NAV3	Ssm	25	291	8.6%	cbioportal
25	SYNE2	Ssm	24	291	8.2%	cbioportal
21	AHNAK2	Ssm	24	291	8.2%	cbioportal
22	HMCN1	Ssm	24	291	8.2%	cbioportal
23	LRP2	Ssm	24	291	8.2%	cbioportal
24	PCLO	Ssm	24	291	8.2%	cbioportal
28	DST	Ssm	23	291	7.9%	cbioportal
26	CREBBP	Ssm	23	291	7.9%	cbioportal
30	FAT1	Ssm	23	291	7.9%	cbioportal
29	EYS	Ssm	23	291	7.9%	cbioportal
27	DNAH2	Ssm	23	291	7.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

HIV+ Tumor Molecular Characterization Project - Cervical Cancer CGCI-HTMCP-CCCGCI

208 cases with simple somatic mutation data · 212 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	112	208	53.8%	gdc
2	MUC4	Ssm	100	208	48.1%	gdc
3	LRCH3	Ssm	98	208	47.1%	gdc
13	PAK2	Ssm	97	208	46.6%	gdc
10	CEP19	Ssm	97	208	46.6%	gdc
9	NCBP2	Ssm	97	208	46.6%	gdc
8	NRROS	Ssm	97	208	46.6%	gdc
12	MUC20	Ssm	97	208	46.6%	gdc
6	NCBP2AS2	Ssm	97	208	46.6%	gdc
5	PIGX	Ssm	97	208	46.6%	gdc
4	SENP5	Ssm	97	208	46.6%	gdc
7	DLG1	Ssm	97	208	46.6%	gdc
11	PIGZ	Ssm	97	208	46.6%	gdc
17	RNF168	Ssm	96	208	46.2%	gdc
16	WDR53	Ssm	96	208	46.2%	gdc
15	RUBCN	Ssm	96	208	46.2%	gdc
14	SLC51A	Ssm	96	208	46.2%	gdc
30	FBXO45	Ssm	96	208	46.2%	gdc
29	SI	Ssm	96	208	46.2%	gdc
28	SMCO1	Ssm	96	208	46.2%	gdc
27	AC069257.3	Ssm	96	208	46.2%	gdc
26	TCTEX1D2	Ssm	96	208	46.2%	gdc
25	PCYT1A	Ssm	96	208	46.2%	gdc
24	MELTF	Ssm	96	208	46.2%	gdc
23	TFRC	Ssm	96	208	46.2%	gdc
22	BDH1	Ssm	96	208	46.2%	gdc
21	TM4SF19	Ssm	96	208	46.2%	gdc
20	TM4SF19-TCTEX1D2	Ssm	96	208	46.2%	gdc
19	UBXN7	Ssm	96	208	46.2%	gdc
18	FYTTD1	Ssm	96	208	46.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017NIH

16 cases with simple somatic mutation data · 16 cases total · 2026-01-13 · mapped to Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	16	43.8%	cbioportal
2	KMT2C	Ssm	5	16	31.3%	cbioportal
3	TAF1	Ssm	4	16	25%	cbioportal
4	ZNF717	Ssm	4	16	25%	cbioportal
5	AGAP4	Ssm	3	16	18.8%	cbioportal
6	FAM136A	Ssm	3	16	18.8%	cbioportal
7	PIK3CA	Ssm	3	16	18.8%	cbioportal
27	FOXA2	Ssm	2	16	12.5%	cbioportal
8	ABCD1	Ssm	2	16	12.5%	cbioportal
9	AHNAK2	Ssm	2	16	12.5%	cbioportal
10	AP3D1	Ssm	2	16	12.5%	cbioportal
11	ARID1A	Ssm	2	16	12.5%	cbioportal
12	ASTE1	Ssm	2	16	12.5%	cbioportal
13	CCDC178	Ssm	2	16	12.5%	cbioportal
14	CHL1	Ssm	2	16	12.5%	cbioportal
15	CHRM5	Ssm	2	16	12.5%	cbioportal
16	COIL	Ssm	2	16	12.5%	cbioportal
17	COL5A1	Ssm	2	16	12.5%	cbioportal
18	DENND4A	Ssm	2	16	12.5%	cbioportal
19	DMAP1	Ssm	2	16	12.5%	cbioportal
20	DNAH11	Ssm	2	16	12.5%	cbioportal
21	DNAH3	Ssm	2	16	12.5%	cbioportal
22	DST	Ssm	2	16	12.5%	cbioportal
23	DYSF	Ssm	2	16	12.5%	cbioportal
24	EPC2	Ssm	2	16	12.5%	cbioportal
25	ERBB3	Ssm	2	16	12.5%	cbioportal
26	FAT3	Ssm	2	16	12.5%	cbioportal
28	FRG1	Ssm	2	16	12.5%	cbioportal
29	FRG2C	Ssm	2	16	12.5%	cbioportal
30	GART	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Endometrioid Carcinoma (CPTAC GDC, 2025) uec_cptac_gdcCPTAC GDC

247 cases with simple somatic mutation data · 442 cases total · 2026-01-14 · mapped to Endometrial Endometrioid Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	194	247	78.5%	cbioportal
2	ARID1A	Ssm	136	247	55.1%	cbioportal
3	PIK3CA	Ssm	105	247	42.5%	cbioportal
4	PIK3R1	Ssm	91	247	36.8%	cbioportal
5	TTN	Ssm	89	247	36%	cbioportal
6	CTNNB1	Ssm	71	247	28.7%	cbioportal
7	KRAS	Ssm	67	247	27.1%	cbioportal
8	OBSCN	Ssm	65	247	26.3%	cbioportal
9	KMT2B	Ssm	62	247	25.1%	cbioportal
10	INPPL1	Ssm	61	247	24.7%	cbioportal
11	KMT2D	Ssm	61	247	24.7%	cbioportal
12	TP53	Ssm	61	247	24.7%	cbioportal
13	CTCF	Ssm	56	247	22.7%	cbioportal
14	SYNE1	Ssm	54	247	21.9%	cbioportal
15	ZFHX3	Ssm	54	247	21.9%	cbioportal
16	PCLO	Ssm	51	247	20.6%	cbioportal
17	MUC16	Ssm	49	247	19.8%	cbioportal
18	MUC5B	Ssm	48	247	19.4%	cbioportal
19	FSIP2	Ssm	47	247	19%	cbioportal
20	CSMD3	Ssm	46	247	18.6%	cbioportal
21	RYR1	Ssm	45	247	18.2%	cbioportal
22	ZFHX4	Ssm	45	247	18.2%	cbioportal
23	JAK1	Ssm	43	247	17.4%	cbioportal
24	RYR2	Ssm	43	247	17.4%	cbioportal
25	DNAH5	Ssm	42	247	17%	cbioportal
26	CHD4	Ssm	41	247	16.6%	cbioportal
27	FAT3	Ssm	41	247	16.6%	cbioportal
28	HERC2	Ssm	41	247	16.6%	cbioportal
29	DNAH17	Ssm	40	247	16.2%	cbioportal
30	FBXW7	Ssm	40	247	16.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-14