- NCIt
- C171576
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Data completeness2 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A lethal form of advanced castration-resistant prostate carcinoma that emerges in the later stages of castration-resistant treatment. It is an adaptive response to androgen receptor pathway inhibition. The morphologic features vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small cell carcinomas to pure small cell carcinomas expressing neuroendocrine markers. Clinically, it manifests with rapidly progressive disease, visceral or lytic bone metastases and bulky tumor masses. Molecular studies have shown the loss of tumor suppressor genes TP53 and RB1.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
Children (0)
Leaf node — no children.
Anatomy
Data updated 2 hours agoSource updated unknowncounters aggregate over descendants
Names
CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.
Key figures
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Data updated 2 hours agoSource updated unknownregistry figures: cdc-wonder · latest year available per metric · counters aggregate over descendants