Aggressive T-Cell Non-Hodgkin Lymphoma — Variants & evidence

Aggressive T-Cell Non-Hodgkin Lymphoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items (5 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ALK R214H1
Crizotinib	Nasal Type Extranodal NK/T-Cell Lymphoma	Predictive	C	Supports Sensitivity Response	—	submitted	EID4827 In a patient with nasal type extranodal NK/T-cell lymphoma harboring ALK R214H mutation, ALK R214H was associated with response to crizotinib monotherapy. Prior to identification of the ALK R214H muta… (full text at CIViC) PMID 27594191 · Thanarajasingam et al., 2016 · Open in CIViC	civic
NOTCH1 L1678P1
Nirogacestat	Adult T-Cell Leukemia/Lymphoma	Predictive	C	Supports Sensitivity Response	3	submitted	EID5921 Genetic evaluation of a single patient with a complete response in a phase 1 trial of PF-03084014 revealed the presence of a known activating NOTCH1 mutation, L1678P. PMID 26407235 · Papayannidis et al., 2015 · Open in CIViC	civic
PLCG1 S345F1
(oncogenic)	Adult T-Cell Leukemia/Lymphoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11795 The PLCG1 S345F mutation has been reported as a hotspot mutation in adult T-cell Leukemia/Lymphoma (ATL). This study performed in vitro characterization of the mutation by identifying an ATL cell line… (full text at CIViC) PMID 36442790 · Prawiro et al., 2023 · Open in CIViC	civic
PRKCB D427N1
(diagnostic)	Adult T-Cell Leukemia/Lymphoma	Diagnostic	D	Supports Positive	3	accepted	EID6654 PRKCB was mutated in 33% of ATLL cases. 93% of these mutations were within the catalytic domain at Asp427. This gene has not been reported to be significantly mutated in any other cancers. Indeed thi… (full text at CIViC) PMID 26437031 · Kataoka et al., 2015 · Open in CIViC	civic
PRKCB Mutation1
(prognostic)	Adult T-Cell Leukemia/Lymphoma	Prognostic	D	Supports Poor Outcome	3	submitted	EID11794 For aggressive adult T cell leukemia/lymphoma (ATL), PRKCB mutations were associated with an adverse outcome (Hard Ratio: 2.07; 95% CI: 1.29-3.31; P-value: 0.003). In this study, 414 ATL patients were… (full text at CIViC) PMID 29084771 · Kataoka et al., 2018 · Open in CIViC	civic

Data updated 23 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.