ALK R214H

CI-VAR-00003767Explore in graph →NP_004295.2:p.Arg214HisNM_004304.4:c.641G>AClinVar 538178 CIViC 1683 rs766999851

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Nasal Type Extranodal NK/T-Cell Lymphoma1
ALK R214H	Crizotinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID4827 In a patient with nasal type extranodal NK/T-cell lymphoma harboring ALK R214H mutation, ALK R214H was associated with response to crizotinib monotherapy. Prior to identification of the ALK R214H muta… (full text at CIViC) PMID 27594191 · Thanarajasingam et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
538178	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Neuroblastoma, susceptibility to, 3; Hereditary cancer-predisposing syndrome	germline	4	Nov 24, 2025	clinvar