Histology
Adenocarcinoma
CI-CAN-00000403Explore in graph →
2,751 active trials43 approved drugs423 evidence items
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Histology
CI-CAN-00000403Explore in graph →
Genomics
162 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
7,237 cases with simple somatic mutation data · 7,237 cases total · 2026-09-01 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC | Ssm | 5,400 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 7,237 |
| 74.6% |
| cbioportal |
| 2 | TP53 | Ssm | 5,295 | 7,237 | 73.2% | cbioportal |
| 3 | KRAS | Ssm | 3,096 | 7,237 | 42.8% | cbioportal |
| 4 | PIK3CA | Ssm | 1,486 | 7,237 | 20.5% | cbioportal |
| 5 | FBXW7 | Ssm | 1,127 | 7,237 | 15.6% | cbioportal |
| 6 | TCF7L2 | Ssm | 1,088 | 7,035 | 15.5% | cbioportal |
| 7 | SMAD4 | Ssm | 1,078 | 7,237 | 14.9% | cbioportal |
| 8 | ARID1A | Ssm | 912 | 7,237 | 12.6% | cbioportal |
| 9 | SOX9 | Ssm | 869 | 7,237 | 12% | cbioportal |
| 10 | BRAF | Ssm | 813 | 7,237 | 11.2% | cbioportal |
| 11 | KMT2D | Ssm | 805 | 7,237 | 11.1% | cbioportal |
| 15 | KMT2B | Ssm | 653 | 6,120 | 10.7% | cbioportal |
| 12 | RNF43 | Ssm | 734 | 7,237 | 10.1% | cbioportal |
| 13 | PTPRS | Ssm | 708 | 7,237 | 9.8% | cbioportal |
| 14 | ZFHX3 | Ssm | 658 | 7,035 | 9.4% | cbioportal |
| 16 | ATM | Ssm | 646 | 7,237 | 8.9% | cbioportal |
| 17 | PTPRT | Ssm | 636 | 7,237 | 8.8% | cbioportal |
| 18 | KMT2C | Ssm | 605 | 7,237 | 8.4% | cbioportal |
| 19 | NOTCH3 | Ssm | 571 | 7,237 | 7.9% | cbioportal |
| 20 | AMER1 | Ssm | 550 | 7,237 | 7.6% | cbioportal |
| 21 | FAT1 | Ssm | 550 | 7,237 | 7.6% | cbioportal |
| 29 | MSH3 | Ssm | 453 | 6,120 | 7.4% | cbioportal |
| 22 | CREBBP | Ssm | 517 | 7,237 | 7.1% | cbioportal |
| 23 | CTNNB1 | Ssm | 503 | 7,237 | 7% | cbioportal |
| 26 | ANKRD11 | Ssm | 468 | 7,035 | 6.7% | cbioportal |
| 44 | PREX2 | Ssm | 404 | 6,120 | 6.6% | cbioportal |
| 24 | GRIN2A | Ssm | 470 | 7,237 | 6.5% | cbioportal |
| 25 | CARD11 | Ssm | 469 | 7,237 | 6.5% | cbioportal |
| 27 | NOTCH1 | Ssm | 459 | 7,237 | 6.3% | cbioportal |
| 28 | BRCA2 | Ssm | 454 | 7,237 | 6.3% | cbioportal |
Data updated 21 days agoSource updated 2026-09-01