Histology
Adenocarcinoma
CI-CAN-00000403Explore in graph →
2,751 active trials43 approved drugs423 evidence items
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Histology
CI-CAN-00000403Explore in graph →
Genomics
162 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
223 cases with simple somatic mutation data · 640 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 160 |
| 223 |
| 71.7% |
| cbioportal |
| 2 | TP53 | Ssm | 120 | 223 | 53.8% | cbioportal |
| 3 | KRAS | Ssm | 96 | 223 | 43% | cbioportal |
| 4 | TTN | Ssm | 80 | 223 | 35.9% | cbioportal |
| 5 | SYNE1 | Ssm | 47 | 223 | 21.1% | cbioportal |
| 6 | LRP1B | Ssm | 40 | 223 | 17.9% | cbioportal |
| 8 | MUC16 | Ssm | 39 | 223 | 17.5% | cbioportal |
| 7 | FAT4 | Ssm | 39 | 223 | 17.5% | cbioportal |
| 9 | FBXW7 | Ssm | 38 | 223 | 17% | cbioportal |
| 10 | LRP2 | Ssm | 35 | 223 | 15.7% | cbioportal |
| 11 | DMD | Ssm | 34 | 223 | 15.2% | cbioportal |
| 12 | DNAH5 | Ssm | 34 | 223 | 15.2% | cbioportal |
| 13 | PIK3CA | Ssm | 33 | 223 | 14.8% | cbioportal |
| 14 | FLG | Ssm | 32 | 223 | 14.3% | cbioportal |
| 16 | FAT2 | Ssm | 30 | 223 | 13.5% | cbioportal |
| 17 | HMCN1 | Ssm | 30 | 223 | 13.5% | cbioportal |
| 15 | ANK2 | Ssm | 30 | 223 | 13.5% | cbioportal |
| 18 | RYR2 | Ssm | 29 | 223 | 13% | cbioportal |
| 19 | COL6A3 | Ssm | 28 | 223 | 12.6% | cbioportal |
| 20 | CSMD1 | Ssm | 28 | 223 | 12.6% | cbioportal |
| 21 | CSMD3 | Ssm | 28 | 223 | 12.6% | cbioportal |
| 22 | SDK1 | Ssm | 27 | 223 | 12.1% | cbioportal |
| 26 | USH2A | Ssm | 26 | 223 | 11.7% | cbioportal |
| 25 | SMAD4 | Ssm | 26 | 223 | 11.7% | cbioportal |
| 24 | PKHD1 | Ssm | 26 | 223 | 11.7% | cbioportal |
| 23 | DNAH2 | Ssm | 26 | 223 | 11.7% | cbioportal |
| 28 | ATM | Ssm | 25 | 223 | 11.2% | cbioportal |
| 27 | AMER1 | Ssm | 25 | 223 | 11.2% | cbioportal |
| 29 | HYDIN | Ssm | 25 | 223 | 11.2% | cbioportal |
| 34 | RYR1 | Ssm | 24 | 223 | 10.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-06