Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA

Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RARA Fusion5
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12333 In this study, the authors explored the role of retinoic acid receptor alpha (RARα) gene rearrangements in acute promyelocytic leukemia (APL) and their connection to the t(15;17) chromosomal transloca… (full text at CIViC) PMID 2170850 · de Thé et al., 1990 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12334 In this study, the authors investigated the role of retinoic acid receptor alpha (RARα) gene rearrangements in acute promyelocytic leukemia (APL), a distinct subtype of acute myeloid leukemia (AML) ch… (full text at CIViC) PMID 2175343 · Longo et al., 1990 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	4	accepted	EID12288 In this study, researchers examined the diagnostic significance of the PML::RARA fusion in acute promyelocytic leukemia (APL, FAB-M3), a subtype of acute myeloid leukemia (AML) associated with the t(1… (full text at CIViC) PMID 38304177 · Santana-Hernández et al., 2024 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	4	accepted	EID12289 This study presents a rare case of acute promyelocytic leukemia (APL) characterized by an atypical PML::RARA fusion transcript resulting from the t(15;17) translocation. The patient, a 44-year-old fem… (full text at CIViC) PMID 17934255 · Ismail et al., 2007 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	4	accepted	EID12292 In this study, the authors investigated the molecular characteristics of acute promyelocytic leukemia (APL) in patients with atypical PML::RARA fusion transcripts. APL is a rare and aggressive leukemi… (full text at CIViC) PMID 30421475 · Iaccarino et al., 2019 · Open in CIViC	civic

Data updated 22 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.