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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
400 stopped studies mapped to Sarcoma and descendants · 90% state a reason
Over the 400 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02557854 | HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric… | Phase 1 | withdrawn | Sep 23, 2015 | Theodore Laetsch | Lack of enrollment | Enrollment / accrual |
| NCT03437070 | Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent… | Phase 1 | withdrawn | Feb 19, 2018 | University of Miami | Sponsor Decision | Sponsor / business decision |
| NCT02879058 | Intraoperative Ultrasound in Laparoscopic or Robotic Myomectomy Patients | N/A | terminated | Aug 25, 2016 | The Cleveland Clinic | Due to inadequate enrollment. | Enrollment / accrual |
| NCT01752569 | A Study of Selumetinib in Patients With Kaposi's Sarcoma(SCART) | Phase 1 / Phase 2 | terminated | Dec 19, 2012 | Sheffield Teaching Hospitals NHS Foundation Trust | Poor recruitment | Enrollment / accrual |
| NCT02255110 | A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic… | Phase 2 | terminated | Oct 2, 2014 | Merck KGaA, Darmstadt, Germany | Sponsor's decision due to negative result of Phase 3 study TH-CR-406/SARC021 | Sponsor / business decision |
| NCT00414076 | Letrozole Versus Observation in Patients With Newly Diagnosed Uterine Leiomyosarcoma | Phase 2 | terminated | Dec 21, 2006 | M.D. Anderson Cancer Center | Low accrual | Enrollment / accrual |
| NCT00020683 | A Phase II Trial of COL-3 in Patients With HIV Related Kaposi's Sarcoma | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Cancer Therapy Evaluation Program's (CTEP's) termination of drug supply | Drug supply |
| NCT02199938 | Identification and Characterization of Molecular Markers in Musculoskeletal Tumors | — | terminated | Jul 25, 2014 | Balgrist University Hospital | Principal Investigator has left the Institution | Investigator |
| NCT02775799 | National Swiss Sarcoma Cohort Study(SwissSARCOS) | — | terminated | May 18, 2016 | Balgrist University Hospital | Principal Investigator has left the Institution | Investigator |
| NCT02785692 | Preoperative IMRT for Soft Tissue Sarcoma of the Extremities and Trunk: Low Rate of Wound… | — | terminated | May 30, 2016 | Balgrist University Hospital | Principal Investigator has left the Institution | Investigator |
| NCT01986829 | Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With… | Phase 2 | terminated | Nov 19, 2013 | Washington University School of Medicine | Slow accrual | Enrollment / accrual |
| NCT00617890 | A Study to Determine the Activity of Robatumumab (SCH 717454) in Participants With… | Phase 2 | terminated | Feb 18, 2008 | Merck Sharp & Dohme LLC | The study was prematurely terminated for strategic reasons, not for a safety concern. | Safety / toxicity |
| NCT00870701 | Observation Versus Post-surgery Radiotherapy After Complete Exeresis in Soft Tissues… | Phase 3 | terminated | Mar 27, 2009 | Institut Claudius Regaud | Slow recruitment rate | Enrollment / accrual |
| NCT00730886 | ExAblate Treatment of Uterine Fibroids for Fertility Enhancement | N/A | terminated | Aug 8, 2008 | InSightec | not stated | Not stated |
| NCT02011126 | Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors | Phase 2 | withdrawn | Dec 13, 2013 | Children's Oncology Group | IND no longer available. | Other (stated, no rule matched) |
| NCT03111069 | Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and… | Phase 1 | withdrawn | Apr 12, 2017 | M.D. Anderson Cancer Center | PI withdrew study | Other (stated, no rule matched) |
| NCT01341496 | Tumor Cell Vaccines and ISCOMATRIX With Chemotherapy After Tumor Removal | Phase 1 | terminated | Apr 25, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02839694 | Adjuvant Oral Decitabine and Tetrahydrouridine With or Without Celecoxib in People… | Phase 1 | withdrawn | Jul 21, 2016 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02331251 | Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus) | Phase 1 / Phase 2 | terminated | Jan 6, 2015 | Western Regional Medical Center | PI not longer at site. | Other (stated, no rule matched) |
| NCT02113683 | Validation of MMS Test for Cancer Monitoring(MMS-TM) | — | terminated | Apr 15, 2014 | MedInnovation GmbH | insufficient recruitment on the part of clinic; study will not resume | Enrollment / accrual |
| NCT01328067 | Study to Evaluate the Safety and Effectiveness of MRgFUS Compared With Myomectomy for the… | N/A | withdrawn | Apr 4, 2011 | InSightec | not stated | Not stated |
| NCT00686842 | PTC299 in Treating Patients With HIV-Related Kaposi Sarcoma | Phase 1 / Phase 2 | terminated | May 30, 2008 | AIDS Malignancy Consortium | Drug supply unavailable. | Drug supply |
| NCT00089544 | Preoperative Thalidomide With Radiation Therapy For Patients With Low-Grade Primary Soft… | Phase 2 | terminated | Aug 9, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00003054 | Paclitaxel in Treating Patients With Recurrent or Persistent Cancer of the Uterus | Phase 2 | terminated | Jun 25, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT01055028 | Paclitaxel + Bevacizumab (Avastin) for the Treatment of Metastatic or Unresectable… | Phase 2 | terminated | Jan 25, 2010 | Stanford University | Poor accrual | Enrollment / accrual |
| NCT01610570 | Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma | Phase 1 / Phase 2 | terminated | Jun 4, 2012 | National Cancer Institute (NCI) | Study was closed to enrollment before dose level one was completed. | Enrollment / accrual |
| NCT00004261 | EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or… | Phase 1 | terminated | Dec 11, 2003 | University Health Network, Toronto | Lack of patient accrual | Enrollment / accrual |
| NCT02736435 | Treatment of Uterine Fibroids With Magnetic Resonance Guided High Intensity Focused… | Phase 3 | withdrawn | Apr 13, 2016 | Thunder Bay Regional Health Research Institute | Lengthy delays and inadequate support to proceed. | Other (stated, no rule matched) |
| NCT01984892 | Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)(Hiltonol) | Phase 2 | terminated | Nov 15, 2013 | Nina Bhardwaj | PI discretion, low enrollment | Enrollment / accrual |
| NCT01418001 | Gemcitabine and Docetaxel in Combination With Pazopanib (Gem/Doce/Pzb) for the… | Phase 1 / Phase 2 | terminated | Aug 16, 2011 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT02164097 | ODSH + ICE Chemotherapy in Pediatric Solid Tumors | Phase 1 | terminated | Jun 16, 2014 | New York Medical College | low accrual | Enrollment / accrual |
| NCT02229981 | Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large…(ABC-102) | Phase 1 / Phase 2 | withdrawn | Sep 3, 2014 | RedHill Biopharma Limited | Study was discontinued due to lack of recruitment. | Enrollment / accrual |
| NCT00623077 | MT2004-30: Tomotherapy for Solid Tumors | Phase 1 | terminated | Feb 25, 2008 | Masonic Cancer Center, University of Minnesota | Replaced by another study | Other (stated, no rule matched) |
| NCT00003926 | Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors | Phase 1 | terminated | May 2, 2003 | Masonic Cancer Center, University of Minnesota | Withdrawn due to slow accrual | Enrollment / accrual |
| NCT00944580 | A Vaccine Study for High Risk Cancers | Phase 1 | withdrawn | Jul 23, 2009 | Penn State University | unexpectedly low screening results leading to poor accrual | Enrollment / accrual |
| NCT01313884 | Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings… | Phase 2 | terminated | Mar 14, 2011 | Stanford University | Study did not reach primary objective; study did not accrue enough patients. | Enrollment / accrual |
| NCT01169350 | 18F-Fluoromisonidazole and Fludeoxyglucose F 18 PET/CT Patients With Soft Tissue Sarcoma | Phase 2 | terminated | Jul 26, 2010 | National Cancer Institute (NCI) | funding source ended earlier than anticipated | Funding |
| NCT02113826 | Pazopanib for Metastatic Alveolar Soft Part Sarcoma | Phase 2 | terminated | Apr 15, 2014 | Seoul National University Hospital | Low accrual rate | Enrollment / accrual |
| NCT02720796 | Patient-Derived Xenograft (PDX) Modeling in Adult Patients With Metastatic or Recurrent… | N/A | terminated | Mar 28, 2016 | Champions Oncology | Recruitment barriers | Enrollment / accrual |
| NCT03007771 | Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild… | Phase 1 | withdrawn | Jan 2, 2017 | Washington University School of Medicine | Decision was made to not go forward with the study | Other (stated, no rule matched) |
| NCT00003521 | Antineoplaston Therapy in Treating Patients With Soft Tissue Sarcoma | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT03149120 | Study of Nivolumab With or Without Pazopanib in Metastatic or Unresectable Soft Tissue… | Phase 2 | withdrawn | May 11, 2017 | NYU Langone Health | No patient enrolled as new similar study will be in system within 3 months | Enrollment / accrual |
| NCT01842789 | Post Market Evaluation of Acessa With TAG(TAG) | N/A | terminated | Apr 30, 2013 | Acessa Health, Inc. | Results to date adequately demonstrated user preference and recovery time. Time to target (Part II)… | Other (stated, no rule matched) |
| NCT02008019 | A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas(CHONRAD) | Phase 2 | suspended | Dec 11, 2013 | Centre Leon Berard | The study was suspended since july 27th 2016 because of unavailability of Everolimus | Other (stated, no rule matched) |
| NCT02210104 | Adoptive Therapy Using Antigen-Specific CD4 T-Cells | Phase 1 | withdrawn | Aug 6, 2014 | M.D. Anderson Cancer Center | Issues with tetramer staining | Other (stated, no rule matched) |
| NCT01130623 | A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors | Phase 1 | withdrawn | May 26, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01236586 | RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell… | Phase 1 | withdrawn | Nov 8, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01469975 | First in Man Study Investigating the Biodistribution, the Safety and Optimal Recommended…(SYNFRIZZ) | Phase 1 | terminated | Nov 10, 2011 | Centre Leon Berard | Too slow accrual. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 19, 2019source: clinicaltrials