Clinical trial · Observational
Preoperative IMRT for Soft Tissue Sarcoma of the Extremities and Trunk: Low Rate of Wound Complications
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Principal Investigator has left the Institution
Summary
Brief summary (as posted)
Postoperative wound healing complications following preoperative radiotherapy represent a severe problem in the treatment of malignant soft tissue tumors, and are reported to be 34% and more. The literature discusses intensely the advantages and disadvantages of this multimodal treatment concept and there are different opinions. The Canadian prospective randomized NCIC SR2 trial showed increased wound complication rates in the study arm receiving preoperative radiation. The Sarcoma Center Zurich pursues mainly this treatment concept and the results shall now be analysed and published. The approach is to show that not only the complication rates are comparable to international bench marks, but also the (still intermediate time) local control rates.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Combined Radiation/ Surgery
- description
- All patients treated with combined radiotherapy and surgery at Balgrist University Hospital and University Hospital Zurich
- interventionNames
- Radiation: Radiation
Primary outcomes (1)
- measure
- Major and minor wound healing complications
- timeFrame
- through study completion, minimum 6 weeks post surgery
Secondary outcomes (2)
- measure
- Local and metastatic disease control based on imaging such as CT scans and MRI
- timeFrame
- maximum 10 years post surgery
- measure
- Overall survival at the latest point of follow- up
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 110 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with a malignant soft tissue tumour * Patients who underwent preoperative radiotherapy at the department of radiation oncology, University Hospital Zurich (USZ) * Surgical treatment at Balgrist University Hospital between 2007 and 2016 Exclusion Criteria: * Vulnerability * Previous chemotherapy * Previous radiotherapy on the affected site * Patient's wish
References
Publications (0)
Data not yet available