Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large B-cell Lymphoma or Kaposi Sarcoma

Inclusion Criteria

1. Pathologically confirmed DLBCL or KS. In the case of patients with DLBCL, the disease must be radiographically refractory to standard therapy, or relapsed following standard therapy (one or more tumors measurable on PET-CT scan). In the case of patients with KS, the disease must be either radiographically or clinically refractory (persistent skin lesions) to standard therapy or relapsed following standard therapy (one or more tumors measurable on CT scan or through direct measurement of skin tumors). Please see caveats for antineoplastic therapies in Exclusion criteria below.
2. For patients with DLBCL, the patient is not a candidate for hematopoietic stem cell transplantation (as determined by medical oncologists at participating institutions) or has failed stem cell transplantation.
3. Tumor progression after receiving standard/approved chemotherapy, or lack of candidacy for standard therapy.
4. One or more tumors measurable on PET-CT scan (DLBCL), CT scan (KS), or by clinical exam of skin (KS).
5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 3.
6. Life expectancy of at least 3 months.
7. Age ≥ 18 years.
8. Signed, written IRB-approved informed consent.
9. A negative pregnancy test (if female).
10. Acceptable liver function:

    * Bilirubin ≤ 3 times upper limit of normal (CTCAE Grade 2 baseline)
    * AST (SGOT), ALT (SGPT) ≤ 3 x ULN (CTCAE Grade 1 baseline)
    * Serum creatinine ≤ 1.5 X ULN (CTCAE Grade 1 baseline)
11. Acceptable hematologic status:

    * Absolute neutrophil count ≥ 1000 cells/mm3
    * Platelet count ≥ 75,000 (plt/mm3) (CTCAE Grade 1 baseline)
    * Hemoglobin ≥ 8 g/dL
12. Urinalysis: No clinically significant abnormalities.
13. PT and PTT ≤ 1.5 X ULN after correction of nutritional deficiencies that may contribute to prolonged PT/PTT.
14. For men and women of child-producing potential, willingness to use of effective contraceptive methods during the study. If female (or female partner of male subject), is either not of childbearing potential (defined as postmenopausal for ≥ 1 year or surgically sterile \[bilateral tubal ligation, bilateral oophorectomy or hysterectomy\]) or practicing one of the following medically acceptable methods of birth control and agrees to continue with the regimen throughout the duration of the study:

    * Oral, implantable or injectable contraceptives for 3 consecutive months before the Baseline/Randomization Visit.
    * Total abstinence from sexual intercourse (≥ 1 complete menstrual cycle before the Baseline/Randomization Visit).
    * Intrauterine device (IUD).
    * Double barrier method (condoms, sponge, diaphragm or vaginal ring with spermicidal jellies or cream).

Exclusion Criteria

1. New York Heart Association Class III or IV, cardiac disease, myocardial infarction within the past 6 months, unstable arrhythmia, or evidence of ischemia on ECG.
2. Pregnant or nursing women. NOTE: Women of child-bearing potential and men must agree to use barrier methods (preferably condoms) or other methods of birth control at your doctor's discretion, or abstain from sexual activity, prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
3. Patients with active, life-threatening bacterial or fungal infections.
4. Treatment with radiation therapy, surgery, chemotherapy, or investigational therapy within one month prior to study entry.
5. Unwillingness or inability to comply with procedures required in this protocol.
6. Serious nonmalignant disease (e.g., hydronephrosis, liver failure, or other conditions) that could compromise protocol objectives in the opinion of the Investigator and/or the Sponsor.
7. Patients who are currently receiving any other investigational agent.
8. Patients who are receiving drugs other than highly active antiretroviral therapy (HAART) or trimethoprim-sulfamethoxazole that are sensitive substrates of CYP450 1A2, 3A4, 2C9, 2D6, or 2C19, or strong inhibitors or inducers of these isozymes that cannot be stopped at least 7 days or 5 half-lives (whichever is longer) before starting treatment with ABC294640 and either replaced with another appropriate medication or not given for the duration of the clinical study. Patients on HAART will be restricted to preferred, potent agents with no demonstrated interactions with CYP450 isoforms for which significant interactions are predicted with ABC294640 (1A2, 2C9, or 2C19 for which ABC294640 IC50 \< 1uM). These include tenofovir, FTC, 3TC, abacavir, darunavir, atazanavir, norvir, raltegravir, dolutegravir, elvitegravir, cobicistat, and maraviroc. Switching of ART prior to study entry is permitted given significant data for improvement/maintenance of HIV suppression when switching regimens in other contexts.
9. Patients who are currently taking Coumadin or Coumadin derivatives.
10. Patients who have received any antineoplastic therapy within 1 month of starting treatment with ABC294640 or who have not adequately recovered from side effects and toxicities of previous antineoplastic therapy.
11. Patients who are currently participating in any other clinical trial of an investigational product.
12. Allergy to radiographic contrast