Clinical trial · Interventional
Preoperative Thalidomide With Radiation Therapy For Patients With Low-Grade Primary Soft Tissue Sarcoma or Thalidomide With Radiation Therapy and Chemotherapy For Patients With High-Grade or Intermediate-Grade Primary Soft Tissue Sarcoma of the Arm, Leg, or Body Wall
A Pilot Phase II Study of Pre-Operative Radiation Therapy and Thalidomide (IND 48832; NSC 66847) for Low Grade Primary Soft Tissue Sarcoma or Pre-Operative MAID/Thalidomide/Radiation Therapy for High/Intermediate Grade Primary Soft Tissue Sarcoma of the Extremity or Body Wall
NCT00089544CI-TRIAL-00032501terminatedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Thalidomide may stop the growth of soft tissue sarcoma by stopping blood flow to the tumor. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and dacarbazine, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving thalidomide together with radiation therapy and/or chemotherapy before surgery may shrink the tumor so that it can be removed. This phase II trial is studying how well giving preoperative (before surgery) thalidomide together with radiation therapy works in treating patients with low-grade primary soft tissue sarcoma, and how well giving thalidomide together with radiation therapy, doxorubicin, ifosfamide, and dacarbazine works in treating patients with high-grade or intermediate-grade primary soft tissue sarcoma of the arm, leg, chest wall, or abdominal wall.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Adult Soft Tissue Sarcoma | Adult Soft Tissue Sarcoma | CURATED_BROADER | 0.78 |
| Stage I Adult Soft Tissue Sarcoma AJCC v7 | Adult Soft Tissue Sarcoma | CURATED_BROADER | 0.78 |
| Stage II Adult Soft Tissue Sarcoma AJCC v7 | Adult Soft Tissue Sarcoma | CURATED_BROADER | 0.78 |
| Stage III Adult Soft Tissue Sarcoma AJCC v7 | Adult Soft Tissue Sarcoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dacarbazine | Drug | Dacarbazine | ALIAS |
| Doxorubicin Hydrochloride | Drug | Doxorubicin | ALIAS |
| Filgrastim | Biological | Filgrastim | ALIAS |
| Ifosfamide | Drug | Ifosfamide | ALIAS |
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
| Radiation Therapy | Radiation | — | UNRESOLVED |
| Thalidomide | Drug | Thalidomide | ALIAS |
| Therapeutic Conventional Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cohort A (chemotherapy, radiation, thalidomide, surgery)
- description
- Patients receive doxorubicin, ifosfamide, and dacarbazine IV continuously on days 1-3, 22-24, and 43-45. Patients receive G-CSF subcutaneously beginning on days 4, 25, and 46 and continuing until blood counts recover. Patients undergo radiotherapy once daily on days 7-11, 14-18, 21, 28-32, 35-39, and 42. Patients receive oral thalidomide once daily on days 7-21 and 26-42. Patients undergo surgical resection between days 84 and 98. Beginning 2 weeks after surgery, patients receive oral thalidomide once daily for 12 months in the absence of unacceptable toxicity.
- interventionNames
- Drug: Dacarbazine
- Drug: Doxorubicin Hydrochloride
- Biological: Filgrastim
- Drug: Ifosfamide
- Other: Laboratory Biomarker Analysis
- Radiation: Radiation Therapy
- Drug: Thalidomide
- Procedure: Therapeutic Conventional Surgery
- type
- EXPERIMENTAL
- label
- Cohort B (thalidomide, radiation, surgery)
- description
- Patients receive oral thalidomide once daily beginning on day 1 and continuing until 1 week before surgery. Patients undergo radiotherapy once daily, 5 days a week, on weeks 1-5. Patients undergo surgical resection between days 77 and 91. Beginning 2 weeks after surgery, patients receive oral thalidomide once daily for 6 months in the absence of unacceptable toxicity.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of primary soft tissue sarcoma * T2a or T2b disease * Superficial or deep tumor * Grade 1, 2, 3, or 4 * Tumor located on the upper extremity (including shoulder), lower extremity (including hip), or trunk * Meets 1 of the following criteria: * Tumor ? 8 cm in maximal diameter and grade 3 or 4 (intermediate or high grade) (cohort A) * Tumor \> 5 cm in maximal diameter and grade 1 or 2 (low grade) (cohort B) * Locally recurrent disease allowed provided there has been no prior radiotherapy to the primary tumor * No histologically confirmed rhabdomyosarcoma, extraosseous Ewing's primitive neuroectodermal tumors, osteosarcoma or chondrosarcoma, Kaposi's sarcoma, angiosarcoma, desmoid tumors, or dermatofibrosarcoma protuberans * No overt evidence of lung metastases (CT scan evidence of small incidental lesions without histologic diagnosis allowed) * No evidence of other metastases * No sarcoma of the head, neck, intra-abdominal, or retroperitoneal region * Performance status - Zubrod 0-1 * At least 2 years * Absolute neutrophil count ? 1,500/mm\^3 * Platelet count ? 120,000/mm\^3 * Hemoglobin ? 8.0 g/dL (cohort A) * No known hypercoagulable disorders, such as the following: * APC resistance (factor V Leiden) * Protein S deficiency * Protein C deficiency * Antithrombin III deficiency * Hyperhomocystinemia * Dysplasminogenemia * High plasminogen activator inhibitor * Dysfibrinogenemia * Antiphospholipid syndrome * Thrombocythemia * Dysproteinemia * Fibrin split products \< 2 times upper limit of normal (ULN) * Fibrinogen \> 200 mg/dL * Bilirubin ? 1.5 mg/dL (1.0 mg/dL for patients with Gilbert's syndrome) * AST and ALT ? 2.0 times ULN * PT and PTT \< 1.25 times ULN (except in patients treated with anticoagulants for unrelated medical conditions \[e.g., atrial fibrillation\]) * No history of hepatic cirrhosis * Creatinine ? 1.5 mg/dL * Creatinine clearance \> 60 mL/min * No atherosclerotic coronary artery disease that required bypass surgery within the past year * No uncompensated coronary artery disease by ECG or physical examination * No myocardial infarction within the past 6 months * No severe or unstable angina within the past 6 months * No uncompensated congestive heart failure * No New York Heart Association class II-IV heart disease * No symptomatic peripheral vascular disease * No history of deep vein thrombosis * Cohort A only: * EF ? 50% within the past 6 months * LVEF \> 50% * No pulmonary embolus except if caused directly by foreign body implants (e.g., central venous catheters or portacaths) * No global neurocognitive symptomatology * No fatigue ? grade 2 * No history of uncontrolled seizures or uncontrolled seizure disorder * No sensory neuropathy ? grade 2 except for localized neuropathy due to mechanical cause or trauma * No other malignancies within the past 3 years except non-invasive malignancies (e.g., carcinoma in situ of the cervix, breast, or oral cavity) or squamous or basal cell skin cancer * No history of uncontrolled myxedema * No hypothyroidism ? grade 3 * No active uncontrolled bacterial, viral, or fungal infection * No other significant illness that would preclude surgery * No other major illness or psychiatric impairment that would preclude study therapy * No known AIDS * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use 2 effective barrier methods of contraception for 4 weeks before, during, and for at least 4 weeks after study treatment * No prior thalidomide * No prior biologic therapy for this tumor * No prior chemotherapy for this tumor * See Disease Characteristics * No prior radiotherapy for this tumor * See Cardiovascular * No other concurrent investigational drugs * No concurrent sedating drugs * No concurrent illegal sedating "recreational" drugs * No concurrent alcohol intake of more than 1 drink per day
References
Publications (0)
Data not yet available
No reference posted for this study.