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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,685 stopped studies mapped to Malignant Thoracic Neoplasm and descendants · 90% state a reason
Over the 1,685 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00042302 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
| NCT00042315 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
| NCT01203163 | Case Analysis on Real Life Incidence of Photodynamic Therapy (PDT) Safety Outcomes(CALIPSO) | — | withdrawn | Sep 16, 2010 | Pinnacle Biologics Inc. | Sponsor cancelled the study | Other (stated, no rule matched) |
| NCT00291850 | Phase II Trial of Dose-dense Paclitaxel and Cisplatin as Neo-adjuvant Chemotherapy for… | Phase 2 | terminated | Feb 15, 2006 | Central European Cooperative Oncology Group | no patient recruitment | Enrollment / accrual |
| NCT01353482 | A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With…(MESO-02) | Phase 1 / Phase 2 | withdrawn | May 13, 2011 | University College, London | UCL CTC were informed by Merck Sharp \& Dohme on 22.08.11 that support for the trial had been… | Other (stated, no rule matched) |
| NCT00253461 | 11C Topotecan PET Imaging | Early Phase 1 | terminated | Nov 15, 2005 | Case Comprehensive Cancer Center | Drugs unavailable:unable to make radioactive topotecan | Other (stated, no rule matched) |
| NCT01052766 | Breathing Synchronized PET/CT Scans for the Detection of Malignant Lung & Liver Lesions… | N/A | terminated | Jan 20, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01109953 | Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold… | — | terminated | Apr 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00892801 | Everolimus and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastasis… | Phase 1 | terminated | May 5, 2009 | Vanderbilt-Ingram Cancer Center | Terminated due to low accrual. Study was closed to accrual prematurely and did not continue on to… | Enrollment / accrual |
| NCT00611650 | Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia | Phase 2 | terminated | Feb 11, 2008 | British Columbia Cancer Agency | Slow recruitment | Enrollment / accrual |
| NCT00998101 | Carboplatin, Ixabepilone, and Cetuximab in Patients With Stage III or Stage IV Non-Small… | Phase 2 | withdrawn | Oct 20, 2009 | UNC Lineberger Comprehensive Cancer Center | Study was withdrawn due issuses related to the science | Other (stated, no rule matched) |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00653367 | Evaluation of Chronic Pain After Nerve Section During Thoracotomy | N/A | withdrawn | Apr 4, 2008 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT00003599 | Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers… | Phase 3 | withdrawn | Sep 13, 2004 | M.D. Anderson Cancer Center | Withdrawn study. | Other (stated, no rule matched) |
| NCT01063400 | Feasibility Study: Comparison of Performance Status With Objective Physical Activity… | — | terminated | Feb 5, 2010 | University of Wisconsin, Madison | lack of funding | Funding |
| NCT00472771 | INNO-206 in Patients With Small Cell Lung Cancer (SCLC) | Phase 2 | withdrawn | May 14, 2007 | CytRx | Terminated due to clinical trial material production delays | Other (stated, no rule matched) |
| NCT00411593 | Phase I-II for Patients With Recurrent or Refractory Non-small Cell Lung Cancer (NSCLC) | Phase 1 / Phase 2 | withdrawn | Dec 14, 2006 | M.D. Anderson Cancer Center | Lack of Patient Accrual | Enrollment / accrual |
| NCT00585819 | Validation of a Novel Thoracic Neoplasm Radiotherapy Image Guidance Technique: A Pilot… | N/A | withdrawn | Jan 3, 2008 | University of Wisconsin, Madison | lack of interest | Other (stated, no rule matched) |
| NCT00554775 | WBRT & Erlotinib in Advanced NSCLC and Brain Metastases(TACTIC) | Phase 2 | terminated | Nov 7, 2007 | University College, London | IDMC made a recommendation to stop the trial as the target for continuing to the 2nd phase was not… | Other (stated, no rule matched) |
| NCT00460551 | Zalutumumab in Combination With Chemo-Radiation in a Certain Type of Lung Cancer | Phase 2 | terminated | Apr 16, 2007 | Genmab | Due to considerations regarding the appropriate therapeutic regimen for these patients. | Other (stated, no rule matched) |
| NCT01449357 | Zalutumumab in Non-Small Cell Lung Cancer (NSCLC) Patients Refractory to Tyrosine Kinase… | Phase 2 | withdrawn | Oct 10, 2011 | Genmab | Trial never initiated | Other (stated, no rule matched) |
| NCT01300702 | Neuropathic in the Acute Post Operative Phase | — | terminated | Feb 23, 2011 | Rigshospitalet, Denmark | recruitment problems | Enrollment / accrual |
| NCT00437749 | A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable… | Phase 3 | terminated | Feb 21, 2007 | CBA Research | slow accrual rate; interim accrual objective met | Enrollment / accrual |
| NCT00830245 | A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR… | Phase 2 | terminated | Jan 27, 2009 | Clinical Research Center for Solid Tumor, Korea | low accrual rate | Enrollment / accrual |
| NCT00970645 | Study Comparing EBUS & EUS to Mediastinoscopy in Staging and Detection of Lung Cancer | N/A | terminated | Sep 2, 2009 | Mayo Clinic | Similar study published results | Other (stated, no rule matched) |
| NCT00530205 | Effects of Radiation Therapy on the Body in Patients With Stage III Non-Small Cell Lung… | — | withdrawn | Sep 17, 2007 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00369447 | A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung… | Phase 1 / Phase 2 | terminated | Aug 29, 2006 | YM BioSciences | The study was closed due to slow accrual. | Enrollment / accrual |
| NCT00872482 | A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain… | Phase 2 | terminated | Mar 31, 2009 | YM BioSciences | Study closed due to low enrollment | Enrollment / accrual |
| NCT00539331 | Phase I/II Study of AZD2171 in Combination With Paclitaxel/Carboplatin in Japanese… | Phase 1 | terminated | Oct 4, 2007 | AstraZeneca | not stated | Not stated |
| NCT00343187 | A Phase II Study of ACZONE™ (Dapsone) Gel, 5% As a Treatment For Tarceva®… | Phase 2 | terminated | Jun 22, 2006 | Allergan | Lack of enrollment | Enrollment / accrual |
| NCT00234468 | Iressa vs Placebo as Maintenance Therapy in Locally Advanced NSCLC | Phase 3 | terminated | Oct 7, 2005 | AstraZeneca | Closed due to insufficient recruitment | Enrollment / accrual |
| NCT00232206 | Trial of Neoadjuvant Docetaxel and Cisplatin for Resectable Non-Small Cell Lung Cancer | Phase 2 | terminated | Oct 4, 2005 | Providence Health & Services | study terminated due to slow accrual | Enrollment / accrual |
| NCT00216216 | Pemetrexed in Patients With Chemosensitive and Chemoresistant Relapsed Small Cell Lung… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | The results from the interim analysis were not favorable to continue this trial. | Efficacy / futility |
| NCT00540280 | Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative… | Phase 3 | suspended | Oct 5, 2007 | King Faisal Specialist Hospital & Research Center | Follow up only | Other (stated, no rule matched) |
| NCT00117351 | VELCADE in Previously Treated Patients With Stage IIIB and IV Bronchioloalveolar… | Phase 2 | terminated | Jul 6, 2005 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00283634 | A Study of Tarceva for Use in Patients With Relapsed or Refractory Metastatic Non-Small… | Phase 2 | terminated | Jan 30, 2006 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00293332 | Docetaxel, Carboplatin, and Bevacizumab in Treating Patients With Stage I, Stage II, or… | Phase 2 | terminated | Feb 17, 2006 | University of California, San Francisco | Terminated due to low subject accrual | Enrollment / accrual |
| NCT00354562 | A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small… | Phase 1 / Phase 2 | terminated | Jul 20, 2006 | Abbott | not stated | Not stated |
| NCT00721981 | An Evaluation of the Clinical Treatment and Patient Values and Preferences of Patients… | — | terminated | Jul 25, 2008 | AstraZeneca | Low Recruitment | Enrollment / accrual |
| NCT00329472 | Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung… | Phase 3 | withdrawn | May 24, 2006 | Samsung Medical Center | poor enrollment | Enrollment / accrual |
| NCT00783471 | Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer…(DOPERLO) | Phase 2 | terminated | Oct 31, 2008 | Hellenic Cooperative Oncology Group | The low accrual rate of the study (30% of the expected accrual rate)/Low efficacy in both treatment… | Efficacy / futility |
| NCT00099879 | Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer | Phase 2 | terminated | Dec 22, 2004 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00359450 | Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non… | Phase 2 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277329 | Study of XL999 in Patients With Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subejcts | Safety / toxicity |
| NCT00491699 | Safety Study of XL999 in Adults With Non-Small-Cell Lung Cancer | Phase 1 | terminated | Jun 26, 2007 | Symphony Evolution, Inc. | The study was stopped due to safety concerns | Safety / toxicity |
| NCT01000896 | Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and… | Phase 1 | withdrawn | Oct 23, 2009 | AstraZeneca | AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical… | Other (stated, no rule matched) |
| NCT00080509 | Effectiveness of KOS-862 in the Treatment of Lung Cancer | Phase 2 | terminated | Apr 7, 2004 | Bristol-Myers Squibb | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 23, 2012source: clinicaltrials