Clinical trial · Observational
Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold Images
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of accrual
Summary
Brief summary (as posted)
The patient has been referred for an FDG PET/CT scan. FDG is a form of sugar that contains a small amount of radioactivity; it is used to see the size and possible spread of cancer in the body. Pictures of the body are taken on a machine called a PET/CT scanner. The purpose of this current study is to see if we, the investigators, can take clearer pictures of the tumor than we could with our routine scan method. This would allow us to better see how FDG is picked up by the tumor. PET/CT is presently one of the best tools for detecting cancer and determining its spread in the body. However, due to breathing motion, PET and CT images may become blurred and the location of the tumor on CT and PET images may not match. We have developed a new method that enables us to reduce image blurring and to measure the tumor more accurately on PET images. In this study we want to compare two kinds of images: those from the standard PET/CT scan, and the PET/CT scan pictures taken with our new method. If successful, we may use this new method for clinical routine in the future.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Breath-Hold PET/CT image set | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Breath-Hold PET/CT image
- description
- In addition to the standard clinical PET/CT images, we will provide a breath-hold PET/CT image set, using the same PET data for both.
- interventionNames
- Other: Breath-Hold PET/CT image set
Primary outcomes (1)
- measure
- To determine if our breath-hold acquisition technique can be implemented in whole-body PET/CT scans.
- timeFrame
- at the time of scan
- description
- Because PET events not satisfying the breathing amplitude selection criteria will be dropped off the final image set, it will be necessary to increase the acquisition time for the FOV's covering the thorax area from 3 min/bed to 5 min/bed to compensate for the reduction in statistics. This should result in a total increase of \~6 min for the whole body scan.
Secondary outcomes (1)
- measure
- To determine if whole body PET/CT improves spatial matching of PET and CT
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participant is capable of providing written consent. * 18 years of age or older. * Patient with a known or suspected FDG-avid malignancy in the torso Exclusion Criteria: * none
References
Publications (0)
Data not yet available