Phase II Trial of Dose-dense Paclitaxel and Cisplatin as Neo-adjuvant Chemotherapy for Operable Stage II and IIA NSCLC

Inclusion Criteria:

* histologic or cytologic diagnosis of NSCLC
* Presence of clinical Stage IIA,IIB or IIA disease
* tumor amenable to curative surgical resection
* Patients with clinically measurable lesions will be enrolled in this study.
* No prior tumor therapy
* Performance status of 0-1 on ECOG Scale
* Patients compliance and geographic proximity that allow adequate follow-up.
* Medical fitness of patient, including respiratory function, adequate for radical NSCLC surgery.

Exclusion Criteria:

* Presence of clinical Stage IIIA disease, according to the revision by Mountain CF of American Joint Committee on Cancer.
* Treatment within the last 30 days with any investigational drug.
* Cocurrent administration of any other tumor therapy, including radiotherapy, cytotoxic chemotherapy, immunotherapy, molecular target therapy.
* Active infection that in the opinion of the investigator would compromise the patient's ability to tolerate therapy.
* pregnancy/breast feeding
* Serious concomitant disorders that would compromise the safety of the patient or compromise the patients ability to complete the study, at the discretion of the investigator.
* poorly controlled diabetes mellitus
* Second primary malignancy that is clinically detectable at the time of consideration for study enrollment.
* History of significant neurological or mental disorder, including seizures or dementia.