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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,685 stopped studies mapped to Malignant Thoracic Neoplasm and descendants · 90% state a reason
Over the 1,685 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00807170 | Investigate the Maximum Tolerated Dose of Vandetanib and Concurrent Whole Brain… | Phase 1 | terminated | Dec 11, 2008 | Sanofi | Very slow recruitment | Enrollment / accrual |
| NCT02126527 | Auranofin and Sirolimus in Treating Patients With Advanced Solid Tumors or Recurrent… | Phase 1 | withdrawn | Apr 30, 2014 | Mayo Clinic | no participants enrolled | Enrollment / accrual |
| NCT00404703 | A Study of Avastin (Bevacizumab) in Combination With Platinum-Based Chemotherapy in… | Phase 2 | terminated | Nov 29, 2006 | Hoffmann-La Roche | Primary (safety) endpoint reached | Safety / toxicity |
| NCT01405846 | Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways…(TIDAL1) | Phase 2 | terminated | Jul 29, 2011 | Papworth Hospital NHS Foundation Trust | Futility | Efficacy / futility |
| NCT02522910 | An Open-label Phase Ib/II Study of BAY 1000394 (Roniciclib) in Combination With Docetaxel… | Phase 1 / Phase 2 | withdrawn | Aug 13, 2015 | Yonsei University | not stated | Not stated |
| NCT00003726 | Lepirudin in Treating Patients With Recurrent or Advanced Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | May 3, 2004 | Dartmouth-Hitchcock Medical Center | Study funding was dropped. | Funding |
| NCT01915524 | Trial of RNActive®-Derived Cancer Vaccine and Local Radiation in in Stage IV Non Small… | Phase 1 | terminated | Aug 5, 2013 | CureVac | Slow recruitment in stratum 3: enrolled only 2 instead of 8 pts. within predicted time | Enrollment / accrual |
| NCT01528137 | Talactoferrin in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer… | Phase 1 | terminated | Feb 7, 2012 | Stanford University | Negative data from another trial led to termination of this trial by sponsor. | Other (stated, no rule matched) |
| NCT02673814 | Phase 2 Trial of Durvalumab With or Without Bavituximab in Patients With Previously… | Phase 2 | withdrawn | Feb 4, 2016 | Peregrine Pharmaceuticals | not stated | Not stated |
| NCT00417248 | Cisplatin/Etoposide/Radiotherapy Followed by Consolidation Sorafenib for Inoperable Stage… | Phase 1 / Phase 2 | terminated | Dec 29, 2006 | Nasser Hanna, M.D. | Negative sorafenib results from ESCAPE trial and safety concerns of regimen | Safety / toxicity |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT00104754 | Liposomal SN-38 in Treating Patients With Small Cell Lung Cancer | Phase 2 | withdrawn | Mar 4, 2005 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT02419170 | Mature Dendritic Cell Vaccination Against Unique Immunogenic Peptides in Patients With… | Early Phase 1 | withdrawn | Apr 17, 2015 | Washington University School of Medicine | Investigator who manufactured the vaccine left the university. | Drug supply |
| NCT00951444 | Gemcitabine Hydrochloride and Carboplatin With or Without MK-0646 as First-Line Therapy… | Phase 2 | withdrawn | Aug 4, 2009 | Alliance for Clinical Trials in Oncology | The study was not activated. | Other (stated, no rule matched) |
| NCT02152059 | A Study to Evaluate the Good and Bad Effects of BIBF1120 in Small Cell Lung Cancer… | Phase 2 | withdrawn | Jun 2, 2014 | AHS Cancer Control Alberta | contract issues | Other (stated, no rule matched) |
| NCT01798485 | A Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in…(Galaxy 2) | Phase 3 | terminated | Feb 25, 2013 | Synta Pharmaceuticals Corp. | The study was stopped after the first Interim Analysis due to futility. | Efficacy / futility |
| NCT00787267 | Phase II Study of Dasatinib in Previously Treated Patients With Advanced NSCLC(TOP0801) | Phase 2 | terminated | Nov 7, 2008 | Duke University | Poor accrual | Enrollment / accrual |
| NCT02277457 | Personalized Adaptive Radiation Therapy With Individualized Systemic Targeted Therapy… | Early Phase 1 | withdrawn | Oct 29, 2014 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT01447589 | Radical Lung Radiotherapy Plus Nelfinavir(NelfLung) | Phase 1 / Phase 2 | withdrawn | Oct 6, 2011 | Oxford University Hospitals NHS Trust | failed to recruit, no suitable patients | Enrollment / accrual |
| NCT02087176 | A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat… | Phase 2 | terminated | Mar 14, 2014 | AstraZeneca | The study was terminated early by the sponsor. | Other (stated, no rule matched) |
| NCT00290537 | Phase II Study of ZD6474 in Advanced NSCLC | Phase 2 | terminated | Feb 13, 2006 | M.D. Anderson Cancer Center | Accrual was suboptimal and increasing the number of patients was not feasible. | Enrollment / accrual |
| NCT02705339 | Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC) | Phase 2 | withdrawn | Mar 10, 2016 | Washington University School of Medicine | Clovis Oncology discontinued rociletinib. | Other (stated, no rule matched) |
| NCT02351505 | Selinexor in Treating Patients With Relapsed Small Cell Lung Cancer | Phase 2 | terminated | Jan 30, 2015 | Erin Bertino | Low patient accrual | Enrollment / accrual |
| NCT00956852 | Study on Systemic and Airway Cytokines and Oxidative Stress in Lung Cancer Patients… | — | terminated | Aug 11, 2009 | The University of Hong Kong | Poor subject recruitment | Enrollment / accrual |
| NCT02651506 | Electromagnetic Navigational Bronchoscopy Vs. Transthoracic Needle Biopsy for the… | Phase 2 | withdrawn | Jan 11, 2016 | St. Joseph's Healthcare Hamilton | not stated | Not stated |
| NCT00063258 | Tarceva Surgery for Resectable Stage IIIA(N2) and IIIB (T4 N2) Non-Small-Cell Lung Cancer | Phase 2 | terminated | Jun 25, 2003 | M.D. Anderson Cancer Center | Low accrual rate | Enrollment / accrual |
| NCT00692380 | Gated Intensity Modulated Radiation Therapy and Concurrent Chemotherapy for Inoperable… | Phase 1 | terminated | Jun 6, 2008 | Virginia Commonwealth University | insufficient accrual | Enrollment / accrual |
| NCT00732303 | Pemetrexed and Radiation for Poor-Risk Stage III Non-Small Cell Lung Cancer | Phase 2 | terminated | Aug 11, 2008 | Hoosier Cancer Research Network | Study terminated due to withdrawal of pharmaceutical funding | Funding |
| NCT00766246 | Phase II Avastin Trial for Stage IIIB/IV NSCLC | Phase 2 | terminated | Oct 3, 2008 | Pharmatech | Withdrawal of funding support | Funding |
| NCT00508313 | Thermal Signature of Patients Undergoing Radiation Therapy | — | withdrawn | Jul 27, 2007 | M.D. Anderson Cancer Center | Study closed early without enrollment. | Enrollment / accrual |
| NCT02002273 | Effect of Regulated Pleural Pressure on Air Leak and Fluid Drainage Following Pulmonary… | N/A | withdrawn | Dec 5, 2013 | Ospedali Riuniti Ancona | not stated | Not stated |
| NCT00087048 | Topotecan in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer | Phase 2 | terminated | Jul 12, 2004 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00402896 | Malignant Pleural Effusion With ZD6474 | Phase 2 | terminated | Nov 22, 2006 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01058902 | The Effect Of Aspirin On Survival in Lung Cancer | Phase 3 | withdrawn | Jan 29, 2010 | Liverpool Heart and Chest Hospital NHS Foundation Trust | failed to achive funding | Funding |
| NCT01819428 | NOV120101 (Poziotinib) for 1st Line Monotherapy in Patients With Lung Adenocarcinoma | Phase 2 | terminated | Mar 27, 2013 | National OncoVenture | Low recruitment | Enrollment / accrual |
| NCT00131586 | Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT00492843 | Loading Dose or Standard Dose of Intravenous Ibandronate in Treating Patients With Lung… | Phase 4 | terminated | Jun 27, 2007 | Chinese Society of Lung Cancer | It is too difficult to recruit suitable patients. | Enrollment / accrual |
| NCT01525446 | Proton Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer | Early Phase 1 | terminated | Feb 3, 2012 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT01565772 | Proton Radiation Therapy With Cisplatin and Etoposide Followed by Surgery in Stage III… | Phase 1 | terminated | Mar 29, 2012 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT01029925 | Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small… | Phase 2 | terminated | Dec 10, 2009 | Jonsson Comprehensive Cancer Center | DSMB determined, due to higher than expected risk/safety concerns, study should be closed. | Safety / toxicity |
| NCT02537561 | Talazoparib in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 1, 2015 | Washington University School of Medicine | The pharmaceutical company did not want to follow through with support for the study. | Sponsor / business decision |
| NCT00812266 | Topotecan and Cisplatin Versus Etoposide and Carboplatin in 1st Line Treatment of… | Phase 3 | terminated | Dec 22, 2008 | Danish Oncological Lung Cancer Group | Slow accrual | Enrollment / accrual |
| NCT02470065 | Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.(REMNANT) | Phase 2 | suspended | Jun 12, 2015 | European Organisation for Research and Treatment of Cancer - EORTC | Study never started | Other (stated, no rule matched) |
| NCT00345059 | The DISTAL-2 Study: Docetaxel Alone or in Combination in Second-line Treatment of…(DISTAL-2) | Phase 3 | terminated | Jun 27, 2006 | National Cancer Institute, Naples | slow accrual | Enrollment / accrual |
| NCT00299390 | Safety and Efficacy Study of a New Chemotherapy Agent to Treat Small Cell Lung Cancer | Phase 2 | terminated | Mar 6, 2006 | Bayer | Since only 1 of the first 10 subjects responded to the study treatment, it was decided to stop the… | Efficacy / futility |
| NCT00986284 | Epidermal Growth Factor Receptor (EGFR) Status Based Gefitinib Neoadjuvant Therapy in Non… | Phase 2 | suspended | Sep 29, 2009 | Tianjin Medical University Cancer Institute and Hospital | Lack of patients and some progressed disease soon after surgery | Other (stated, no rule matched) |
| NCT02629848 | Study of Motesanib (AMG 706) in Combination With Paclitaxel and Carboplatin for Advanced… | Phase 3 | terminated | Dec 14, 2015 | Takeda | Sponsor decision to terminate the study because the study did not meet the primary endpoint. | Sponsor / business decision |
| NCT01431378 | Pilot Study of Model Based Iterative Reconstruction Using 64-Slice(MBIR) | — | terminated | Sep 9, 2011 | GE Healthcare | Feasibility study, sufficient amount of data collected. | Other (stated, no rule matched) |
| NCT00988169 | Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With… | Phase 2 | terminated | Oct 2, 2009 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01482572 | Feasibility of Mutational Analysis of Non-Small Cell Lung Cancer (NSCLC) Using Low-volume… | — | withdrawn | Nov 30, 2011 | Samsung Medical Center | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 29, 2016source: clinicaltrials