Gated Intensity Modulated Radiation Therapy and Concurrent Chemotherapy for Inoperable NSCLC

Inclusion Criteria:

* Patients with histologically-proven, by biopsy or cytology, unresectable lung cancer of the following histologic types: squamous cell carcinoma, adenocarcinoma, large cell carcinoma, non-small cell carcinoma, not otherwise specified.
* Patient with AJCC Stage IIIA-IIIB, if all detectable tumor can be encompassed by radiation therapy fields, including both the primary tumor and the involved regional lymph nodes.
* 18-fluoro-2-deoxyglucose positron emission tomography required for staging and image fusion for treatment planning.
* Atelectasis, if present, must be less than one lung.
* Patients must have granulocytes \>1500/µl; platelets \>100,000/µl; bilirubin \< 1.5 mg/dl; AST(SGOT) \< 2 ULN; serum creatinine \< 2.0 mg/dl.
* Zubrod Score 0-1.
* FEV1 must be \>1.0 L.
* Patients must sign a study-specific informed consent form prior to study entry
* Patients must have measurable disease on the planning CT.
* Patient must have a completed the IMRT plan and the attending physician must have reviewed and approved the dose volume histograms as follows (based on treatment planning to the Phase 4 dose level): total lung V20 \< 30%, mean esophageal dose \< 34 Gy, the esophageal V55 \< 30%, the heart V40 \< 50%.
* No prior or concurrent malignancy except non-melanomatous skin cancer unless disease-free for one year or more; no prior lung cancer within last two years.
* No prior RT to thorax.
* No previous chemotherapy or previous biologic response modifiers for current lung cancer or within the past five (5) years.
* No distant metastases or supraclavicular lymph node involvement or significant atelectasis.
* No clinically significant pleural effusions, pericardial effusions or superior vena cava syndrome.

Exclusion Criteria:

* Undifferentiated small cell (oat cell or high grade neuroendocrine) carcinoma, any stage.
* Stage I, II or IV NSCLC.
* Complete tumor resection, recurrent disease, or those patients eligible for definitive surgery.
* Concurrent malignancy except non-melanomatous skin cancer or prior cancer unless disease-free for one year or more.
* Prior radiation therapy to the thorax.
* Previous chemotherapy or previous biologic response modifiers for current lung cancer or within the past five (5) years.
* Distant metastases or supraclavicular lymph node involvement, or atelectasis of an entire lung.
* Patients who have not had the pre-treatment evaluations in Section 4.0 or evaluations performed \> 8 weeks prior to study entry.
* Patients with clinically significant pleural effusions, pericardial effusions or superior vena cava syndrome.
* Prior lung cancer within the last two years.
* Patients who have significant atelectasis and in whom the CT definition of the gross tumor volume(GTV) is difficult to determine.
* Pregnant or lactating females. It is not known what effects this treatment may have on the developing fetus.