Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small Cell Lung Cancer (NSCL)

Inclusion Criteria:

* Patients must have histologically or cytologically confirmed metastatic breast cancer or Stage IIIb or IV non-small cell lung cancer.
* Must have measurable disease as defined by at least one target lesion by RECIST criteria that has not been irradiated.
* Progressive disease after prior chemotherapy or patient refusal of these chemotherapy options.

  * Breast Cancer

    * Patients should have received two prior lines of chemotherapy. This should include prior anthracycline and taxane therapy, either in the adjuvant or metastatic setting.
    * HER-2 positive breast cancer should have received Trastuzumab, in either the adjuvant or metastatic setting.
    * Estrogen Receptor positive breast cancer should have received at least one prior hormonal therapy, either in the adjuvant or metastatic setting.
  * Non-small cell lung cancer patients should have received at least platinum based chemotherapy in the adjuvant, neoadjuvant or metastatic setting.
* Age \> 18 years.
* ECOG performance status \< 2.
* Life expectancy of greater than 12 weeks.
* Patients must have normal organ and marrow function as defined below:

  * Absolute neutrophil count \>1,500/mcL
  * Hemoglobin \>9.0 g/dL
  * Platelets \>100,000/mcL
  * Total bilirubin \<1.5 X upper limit of normal (ULN)
  * AST (SGOT) and ALT (SGPT) \<2.5 X ULN or \<5 X ULN in the presence of live metastases.
  * Creatinine \<1.5 X ULN
* Recovery to baseline or, at most, grade 1 of all drug-related toxicities due to prior chemotherapy, radiation, hormonal therapy, or molecular targeted therapy, except for alopecia.
* Ejection fraction by MUGA scan or echocardiogram must be within normal range.
* Women of childbearing potential must have a negative pregnancy test and women and men must agree to use adequate contraception prior to study entry, for the duration of study participation and for 30 days after the last dose of study therapy.
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Patients who have had chemotherapy, hormonal therapy, molecular targeted therapy, or radiotherapy within 4 weeks prior to receiving first dose of DCA. An exception will be made for palliative radiation to bone which must have been completed 10 days prior to the first dose of DCA. An exception will also be made for HER-2 positive BC who can continue to receive Trastuzumab during therapy with DCA.
* Patients who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
* Patients may not be receiving any other investigational agents, chemotherapy, immunotherapy, radiotherapy, or molecular targeted agents.
* Active CNS metastasis.
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to DCA.
* Due to the possibility of peripheral sensorimotor neuropathy from DCA, the presence of any grad peripheral neuropathy due to prior medical condition (such as multiple sclerosis), medications, or other etiologies.
* Any psychological, familial, sociological, or geographical conditions that do not permit medical follow-up and compliance with the study protocol.
* Uncontrolled concurrent illness including, but not limited to, ongoing or active infection (requiring parenteral anti-biotics), symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* Pregnant women are excluded from this study.
* HIV-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with DCA.
* 2 years must have elapsed since the initial curative procedure for other malignancies, except for in situ cervical cancer, non-melanoma skin cancer, and localized prostate cancer after curative therapy such as surgery, or radiation.
* Patient history of inflammatory bowel disease, malabsorption syndrome, condition causing chronic diarrhea and requiring active therapy or substantial amount of small bowels or stomach removed that may impair absorption of DCA.
* Therapeutic anticoagulation will be allowed with Heparin or LMWH but not with Coumadin.
* Any history of nephrolithiasis because of possible increase in urinary oxalate with DCA and correlation with nephrolithiasis.