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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,672 stopped studies mapped to Malignant Reproductive System Neoplasm and descendants · 89% state a reason
Over the 1,672 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00598858 | Neoadjuvant Docetaxel on Newly Diagnosed Intermediate and High Grade Cancer of the…(2007-5904) | Phase 2 | withdrawn | Jan 23, 2008 | John P. Fruehauf | Halted due to zero accrual and lack of funding | Enrollment / accrual |
| NCT02035345 | Slowed Carboplatin Infusion for Ovarian Cancer Patients Receiving Carboplatin Re-Treatment | Phase 4 | terminated | Jan 14, 2014 | Massachusetts General Hospital | Extended Carboplatin Infusion did not Reduce Frequency of Hypersensitivity Reactions | Other (stated, no rule matched) |
| NCT00565227 | Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and… | Phase 1 | terminated | Nov 29, 2007 | University of Michigan Rogel Cancer Center | closed due to toxicity | Safety / toxicity |
| NCT00637390 | A Phase I Study of Alemtuzumab in Patients With Relapsed Ovarian/Primary Peritoneal… | Phase 1 | terminated | Mar 18, 2008 | University of Michigan Rogel Cancer Center | Genzyme will no longer supply the study drug for this trial as it does not believe the study will… | Drug supply |
| NCT02404428 | Utilizing MRI to Study the Effect of Sulforaphane on Prostate Cancer(ESCAPE-ING) | N/A | terminated | Mar 31, 2015 | Quadram Institute Bioscience | Problems with recruitment | Enrollment / accrual |
| NCT02645591 | Randomized AmnioFix Study During Radical Prostatectomy | Phase 2 | withdrawn | Jan 1, 2016 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00767845 | Symptom Management in African-American Men With Localized Prostate Cancer | — | withdrawn | Oct 7, 2008 | Baylor College of Medicine | No subjects were enrolled here or at UCSF. | Enrollment / accrual |
| NCT01061606 | Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus | Phase 2 | terminated | Feb 3, 2010 | National Cancer Institute (NCI) | Poor accrual | Enrollment / accrual |
| NCT00842582 | Azacitidine With Carboplatin and Paclitaxel for Newly Diagnosed Ovarian Cancer | Phase 1 | withdrawn | Feb 12, 2009 | Loyola University | No enrollment. Unable to recruit due to lack of eligible patients. | Enrollment / accrual |
| NCT00933426 | Lenalidomide and Paclitaxel in Prostate Cancer | Phase 1 | terminated | Jul 7, 2009 | M.D. Anderson Cancer Center | Terminated early due to slow accrual as Phase I dose escalation study. | Enrollment / accrual |
| NCT01227941 | MK-4827 in Combination With Pegylated Liposomal Doxorubicin in Participants With Advanced… | Phase 1 | terminated | Oct 25, 2010 | Tesaro, Inc. | not stated | Not stated |
| NCT01705405 | Merging of Endoscopic and Ultrasound Images for Laparoscopic Surgery(FEE) | N/A | terminated | Oct 12, 2012 | AdministrateurCIC | due to a problem of device | Other (stated, no rule matched) |
| NCT01761812 | Multiparametric MRI for Prostate Cancer Localization and Characterization: New Methods | N/A | terminated | Jan 7, 2013 | Sunnybrook Health Sciences Centre | Inadequate accrual | Enrollment / accrual |
| NCT02279576 | Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG)(PAZOPEN-SOGUG) | Phase 2 | terminated | Oct 31, 2014 | Spanish Oncology Genito-Urinary Group | The low recruitment of patients will not allow to complete the study with the required number of… | Enrollment / accrual |
| NCT02656563 | Radium 223 Following Intermittent ADT(RAND) | Phase 2 | withdrawn | Jan 15, 2016 | Canadian Urology Research Consortium | not stated | Not stated |
| NCT02667925 | Study of the Isotopic Distribution of Intraperitoneal Chemotherapy for Peritoneal…(ISOTOVE) | N/A | withdrawn | Jan 29, 2016 | Centre Jean Perrin | Because of the obsolescence of the study | Other (stated, no rule matched) |
| NCT00862836 | Addition of Vandetanib to Standard Therapy Pegliposomal Doxorubicin (PLD)(ZACFAST) | Phase 1 / Phase 2 | terminated | Mar 17, 2009 | Genzyme, a Sanofi Company | Lack of efficacy | Efficacy / futility |
| NCT01032447 | Overcoming Obstacles to Clinical Trials Enrollment Through a Navigator Program | — | terminated | Dec 15, 2009 | Stanford University | not stated | Not stated |
| NCT02169063 | Carbon-11 Acetate and Fluorine F 18 Sodium Fluoride PET as a Biomarker of Treatment… | N/A | withdrawn | Jun 20, 2014 | University of Washington | not stated | Not stated |
| NCT02042495 | Endometrial Cancer Biomarker Changes Following Exposure to Metformin | Phase 2 | withdrawn | Jan 23, 2014 | Jewish General Hospital | Did not obtain Health Canda approval for drug use in reasonable time and moved onward to new trial | Other (stated, no rule matched) |
| NCT00590967 | A Phase II Study of Extended Field IMRT External Beam Irradiation and Intracavitary… | Phase 2 | terminated | Jan 11, 2008 | Washington University School of Medicine | Due to low accrual | Enrollment / accrual |
| NCT02469116 | Carboplatin Plus Docetaxel With Day 2 Pegylated G-CSF (Neulasta®) in Patients With… | Phase 2 | terminated | Jun 11, 2015 | Washington University School of Medicine | Sponsor withdrew financial support | Funding |
| NCT02348398 | Phase II Study of Pazopanib and Topotecan in Cervical Cancer | Phase 2 | withdrawn | Jan 28, 2015 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00691899 | A Study to Assess the Effects of MK0822 in Prolonging Time to First Bone Metastasis in… | Phase 3 | withdrawn | Jun 6, 2008 | Merck Sharp & Dohme LLC | Withdrawn for administrative reasons | Other (stated, no rule matched) |
| NCT02281279 | Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Nov 3, 2014 | Mayo Clinic | not stated | Not stated |
| NCT02083536 | LDFWART With Docetaxel in Patients With Platinum-Resistant Recurrent Ovarian Carcinoma | Phase 1 | withdrawn | Mar 11, 2014 | University of Miami | Study voluntarily stopped by Principal Investigator due to lack of accrual. | Investigator |
| NCT01555073 | Preemptive Analgesia Following Uterine Artery Embolization | Phase 4 | terminated | Mar 15, 2012 | Northwestern University | Subjects did not meet inclusion criteria | Other (stated, no rule matched) |
| NCT02627430 | Talazoparib and HSP90 Inhibitor AT13387 in Treating Patients With Metastatic Advanced… | Phase 1 | withdrawn | Dec 11, 2015 | National Cancer Institute (NCI) | Other - Protocol moved to Withdrawn | Other (stated, no rule matched) |
| NCT01379378 | Male Stress Urinary Incontinence and Sexual Health | — | withdrawn | Jun 23, 2011 | Stanford University | not stated | Not stated |
| NCT02678520 | Clinical Trial Comparing 3-D RT vs. IMRT in Post- Prostatectomy Prostate Cancer Patients | Phase 2 | withdrawn | Feb 9, 2016 | University of Kansas Medical Center | PI no longer at institution. Study terminated prior to enrolling subjects. | Enrollment / accrual |
| NCT01652014 | Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With… | Phase 2 | withdrawn | Jul 27, 2012 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT00003858 | Mitoxantrone Following Surgery in Treating Patients With Prostate Cancer at High Risk for… | Phase 2 | withdrawn | Sep 14, 2004 | Alliance for Clinical Trials in Oncology | The study was not activated. | Other (stated, no rule matched) |
| NCT01481441 | Quantification of Contrast Enhanced Ultrasound (CEUS) in the Detection of Prostate Cancer(AMC_2011_190) | N/A | terminated | Nov 29, 2011 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | New study protocol started including targeted biopsies | Other (stated, no rule matched) |
| NCT00861471 | Docetaxel (Taxotere) and Imatinib Mesylate (Gleevec) in Hormone Refractory Prostate Cancer | Phase 1 / Phase 2 | terminated | Mar 13, 2009 | NYU Langone Health | due to slow accrual | Enrollment / accrual |
| NCT01003938 | Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer | Phase 2 | terminated | Oct 29, 2009 | NYU Langone Health | due to administrative issue and financial sponsor decision to suspend ovarian cancer studies | Funding |
| NCT00003682 | Methylprednisolone With or Without Doxorubicin in Treating Patients With Metastatic… | Phase 3 | terminated | Jan 27, 2004 | UNICANCER | lack of inclusions | Other (stated, no rule matched) |
| NCT00003852 | Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients… | Phase 2 | terminated | Jan 27, 2004 | UNICANCER | lack of patient inclusion | Other (stated, no rule matched) |
| NCT00664196 | Trial of Anti-PSMA Designer T Cells in Advanced Prostate Cancer After Non-Myeloablative… | Phase 1 | suspended | Apr 22, 2008 | Roger Williams Medical Center | Funding | Funding |
| NCT02140138 | An Open Label Randomised Trial of RNActive® Cancer Vaccine in High Risk and Intermediate… | Phase 2 | terminated | May 16, 2014 | CureVac | Recruitment was terminated after enrolment of 35 instead of 36 evaluable patients for… | Enrollment / accrual |
| NCT01658527 | TAK-700 in Castration Resistant Prostate Cancer | Phase 2 | withdrawn | Aug 7, 2012 | European Organisation for Research and Treatment of Cancer - EORTC | Pharmaceutical company has terminated orteronel (TAK-700) development for Prostate Cancer | Sponsor / business decision |
| NCT00503984 | A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate… | Phase 1 / Phase 2 | terminated | Jul 19, 2007 | University of Miami | Withdrawal of Funding | Funding |
| NCT00671606 | Hysteroscopic Lymphatic Mapping for Endometrial Cancer | Phase 2 | terminated | May 5, 2008 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00216060 | Risedronate to Prevent Skeletal Related Events in Patients With Metastatic Prostate… | Phase 3 | terminated | Sep 22, 2005 | Christopher Sweeney, MBBS | Terminated due to low accrual | Enrollment / accrual |
| NCT01173146 | Imaging of Residual Tumor During Prostatectomy | — | withdrawn | Jul 30, 2010 | Spectros Corporation | Costs for antibody production rose; supplemental funding request not approved. | Funding |
| NCT00985738 | Role of Dutasteride in Patients Undergoing 3D Mapping Biopsy in Early Stage Prostate… | Phase 2 | terminated | Sep 28, 2009 | University of Colorado, Denver | Low recruitment | Enrollment / accrual |
| NCT00801996 | Epidemiologic, Clinical and Genetic Profile of Prostate Cancer in Arab Countries(ProstateCA) | — | withdrawn | Dec 4, 2008 | Weill Medical College of Cornell University | Closed by Investigator | Investigator |
| NCT01356329 | Efficacy and Safety of the LovenoxTM (Enoxaparin) Versus HeparinTM Gynecologic Oncology…(Lovenox) | Phase 3 | suspended | May 19, 2011 | National Guard Health Affairs | Difficulty in enrolling patients | Enrollment / accrual |
| NCT00529464 | Spectroscopy Versus Standard Care in Cervical Cancer Patients | Phase 3 | terminated | Sep 14, 2007 | M.D. Anderson Cancer Center | Two participants enrolled, both inevaluable. | Enrollment / accrual |
| NCT01981707 | F-choline PET in Early Response Assessment for Castration Resistant Prostatic Cancer(PRECHOL) | Phase 2 / Phase 3 | terminated | Nov 11, 2013 | University Hospital, Grenoble | enrollment default | Enrollment / accrual |
| NCT02512120 | Volume Controlled Ventilation vs Autoflow-volume Controlled Ventilation(VCVAFVCV) | N/A | withdrawn | Jul 30, 2015 | Korea University Anam Hospital | The backgroud of this study was not well discussed. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 8, 2016source: clinicaltrials