Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer

Inclusion Criteria:

1. Histologically or cytologically proven, previously treated, epithelial ovarian cancer, and/or serous ovarian cancer.
2. Evaluable disease with CA125 levels two times the upper limit of normal for the institution (\>50u/ml ) on two occasions at least one week apart is required in order to apply CA-125 response criteria.
3. Previously treated for ovarian cancer with a taxane and platinum based regimen. and an additional topotecan regimen (any number of chemotherapy or biologic therapies are allowed; including prior erlotinib are allowed)
4. Age \>= 18 years.
5. Minimum life expectancy: 4 months.
6. ECOG (Eastern Cooperative Oncology Group) performance status 0,1, or 2. 0: Fully active, unrestricted activities of daily living. 1: Ambulatory, but restricted in strenuous activity. 2: Ambulatory, and capable of self care. Unable to work. Out of bed for greater than 50% of waking hours.
7. Complete blood count (CBC) performed less than seven days prior to enrollment and have an absolute neutrophil count \>1.0 X 10\^9/L, and a platelet count \>100 X 10\^9/L.
8. Serum chemistry panel drawn less than seven days prior to enrollment and have a total bilirubin \<= 1.5 X the institutional upper limit of normal (IULN), or SGOT/AST is \< 2.5 X IULN.
9. Serum creatinine \<= 1.5 X institutional upper limit of normal (IULN). If the serum creatinine level is \>= 1.5 IULN, but the serum creatinine clearance \>= 50 mg/dL, then the subject can enter the study.
10. Central line access.
11. Signed written informed consent (approved by the Institutional Review Board \[IRB\]/Ethics Committee) obtained prior to study entry.

Exclusion Criteria:

If the answer to any of the exclusion criteria is YES, the subject is NOT ELIGIBLE for the study.

1. Presence of active cancer other than that described in Section 3.1.criteria (a), with the exception of a diagnosis of synchronous occurrence of adenocarcinoma in ovary and uterus.
2. Uncontrolled intercurrent illness not limited to infection, symptomatic congestive heart failure, or unstable angina pectoris, or cardiac arrhythmia.
3. Acute toxicity of prior chemotherapy is still present
4. History of severe allergic reaction to erlotinib
5. Unresolved sequelae resulting from any surgical procedures.
6. Symptomatic, untreated brain metastases. Patients with untreated brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
7. Lactating or pregnant. The investigational agent topotecan may be toxic to the developing fetus or nursing infant and poses unknown health risks. Documentation of a negative, serum HCG pregnancy test is required for women of child bearing potential (WOCBP) within 2 weeks prior to the start of treatment. WOCBP is defined as women who have not been naturally postmenopausal for at least 12 consecutive months or no previous surgical sterilization. A negative pregnancy test within 2 weeks prior to start of treatment is required.
8. Women of childbearing potential must use effective contraception throughout the time they are on study. Before entering this trial, patients must be made aware of the risk in becoming pregnant.
9. Receipt of any investigational drug within 28 days before beginning treatment with study drug and/or concomitant treatment with other investigational agents.
10. Patients with a history of poorly controlled gastrointestinal disorders that could affect absorption of erlotinib (e.g. Crohn's, ulcerative colitis, etc)