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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,061 stopped studies mapped to Malignant Neoplasm of Unknown Primary and descendants · 91% state a reason
Over the 2,061 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01368003 | STA-9090 in Castration-Resistant Prostate Cancer With Assessment of Androgen Receptor… | Phase 2 | withdrawn | Jun 7, 2011 | Toni Choueiri, MD | Loss of funding. | Funding |
| NCT01348503 | Lenalidomide in Combination With a Fixed Dose of Sorafenib for the Treatment of… | Phase 1 | terminated | May 5, 2011 | Indiana University | Treatment was ineffective | Other (stated, no rule matched) |
| NCT01009203 | Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible,… | Phase 2 | terminated | Nov 6, 2009 | New Mexico Cancer Research Alliance | High patient withdrawal rate | Other (stated, no rule matched) |
| NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for… | Phase 2 | terminated | Feb 27, 2012 | Egyptian Society of Liver Cancer | After interim results data showed no evidence of a difference between both groups | Other (stated, no rule matched) |
| NCT00574483 | Treatment of Advanced Renal Cell Carcinoma With Quinacrine | Phase 2 | withdrawn | Dec 17, 2007 | Cleveland BioLabs | reevaluation of compound development | Other (stated, no rule matched) |
| NCT01419002 | Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in…(Net-Pac) | Phase 3 | terminated | Aug 17, 2011 | CHIR-Net | lack of recruitment | Enrollment / accrual |
| NCT01050283 | A Study to Evaluate [18F]-FDG PET (Fluorodeoxyglucose-positron) in Patients With… | Phase 1 | terminated | Jan 15, 2010 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT02507076 | Isolated Limb Perfusion With Melphalan in Treating Patients With Stage IIIB-IV Melanoma… | N/A | withdrawn | Jul 23, 2015 | Albert Einstein College of Medicine | no enrollment | Enrollment / accrual |
| NCT00857714 | Lapatinib for Treatment of Ductal Carcinoma In Situ (DCIS) of the Breast | N/A | terminated | Mar 9, 2009 | Indiana University | Terminated due to low accrual | Enrollment / accrual |
| NCT01686880 | Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular…(TRYPHON) | Phase 2 | terminated | Sep 18, 2012 | Jules Bordet Institute | poor recruitment and an unexpected low treatment rate | Enrollment / accrual |
| NCT02482909 | A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular… | N/A | terminated | Jun 26, 2015 | Seoul National University Hospital | The post-treatment recurrence rate was expected to be different between two treatment groups. | Other (stated, no rule matched) |
| NCT00176280 | Randomized Phase 2 Trial of Pre-chemotherapy Leukine vs. Leukine-Dexamethasone in… | Phase 2 | withdrawn | Sep 15, 2005 | University of Kentucky | Slow accrual | Enrollment / accrual |
| NCT01487499 | Bronchoscopic Intratumoral Chemotherapy for Small Cell Lung Cancer (SCLC)(SCLC) | Phase 3 | terminated | Dec 7, 2011 | University of Florida | Unable to enroll adequate number of participants | Enrollment / accrual |
| NCT01775280 | Response of Hepatic Tumors to Radioembolization(RESRAD) | Phase 2 | withdrawn | Jan 24, 2013 | University of Zurich | Lack of enrollment | Enrollment / accrual |
| NCT01421316 | Hair-sparing Whole Brain Radiotherapy | Phase 2 | terminated | Aug 22, 2011 | University Hospital, Ghent | No reduction in hair loss 1 month after treatment | Other (stated, no rule matched) |
| NCT02162641 | Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer(R-SeNSAR) | — | withdrawn | Jun 13, 2014 | The Christie NHS Foundation Trust | The study was terminated early as it failed to recruit. | Enrollment / accrual |
| NCT00053235 | Research Study in Patients With Advanced Ovarian Epithelial Cancer | — | withdrawn | Jan 28, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00119314 | Gemcitabine, Docetaxel, and Capecitabine in Treating Patients With Cancer of Unknown… | Phase 2 | withdrawn | Jul 13, 2005 | University of Medicine and Dentistry of New Jersey | slow accrual | Enrollment / accrual |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT01215578 | Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated…(NET) | Phase 2 | terminated | Oct 6, 2010 | Assistance Publique - Hôpitaux de Paris | lack of recruitement | Enrollment / accrual |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00253526 | Gemcitabine Hydrochloride With or Without Bevacizumab in Treating Patients Who Are… | Phase 2 | withdrawn | Nov 15, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01832974 | Possible New Therapy for Advanced Cancer | Phase 1 | terminated | Apr 16, 2013 | INSYS Therapeutics Inc | Business decision by the sponsor during Phase 1. | Sponsor / business decision |
| NCT00469469 | Treatment Study Using Bevacizumab for Patients With Adrenocortical Carcinoma | Phase 2 | withdrawn | May 4, 2007 | Dartmouth-Hitchcock Medical Center | unable to enroll subjects into the study | Enrollment / accrual |
| NCT02156180 | Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma | — | suspended | Jun 5, 2014 | Queensland Centre of Excellence for Head and Neck Cancer | Awaiting funding to facilitate selected-ion flow-tube mass spectrometry (SIFT/MS) | Funding |
| NCT00073450 | Study of Lonafarnib in Patients With Recurrent Squamous Cell Carcinoma of the Head and… | Phase 2 | terminated | Nov 24, 2003 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01029418 | AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Dec 10, 2009 | National Cancer Centre, Singapore | The phase II portion was not conducted due to funding issue. | Funding |
| NCT01801163 | A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With… | Phase 1 | withdrawn | Feb 28, 2013 | Indiana University | Trial had no patients accrued while open | Enrollment / accrual |
| NCT01071564 | RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or… | Phase 1 | terminated | Feb 19, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00081900 | A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible… | Phase 1 / Phase 2 | terminated | Apr 28, 2004 | Genzyme, a Sanofi Company | This study was terminated early by Genzyme because there were insufficient data to support clinical… | Other (stated, no rule matched) |
| NCT02023541 | Proton Beam Therapy to Treat Esophageal Cancer | Phase 1 | terminated | Dec 30, 2013 | Washington University School of Medicine | Lack of insurance coverage for proton beam treatment | Other (stated, no rule matched) |
| NCT00930345 | Biological, Pathological and Imagery Markers in the First-line Treatment of Metastatic…(PREINSUT) | Phase 4 | terminated | Jun 30, 2009 | Assistance Publique - Hôpitaux de Paris | not stated | Not stated |
| NCT01732432 | Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC)(EAOC) | — | withdrawn | Nov 22, 2012 | University Hospital, Basel, Switzerland | not stated | Not stated |
| NCT01547676 | Clamped or Unclamped Surgery in Treating Patients With Kidney Cancer | N/A | terminated | Mar 8, 2012 | University of Southern California | P.I. decided to terminate study due to multiple unresolved issues | Other (stated, no rule matched) |
| NCT01953952 | Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage… | Phase 2 | withdrawn | Oct 1, 2013 | Radiation Therapy Oncology Group | Slow accrual | Enrollment / accrual |
| NCT02059967 | Phase I IGART Study Using Active Breathing Control and Simultaneous Boost for Patients… | Phase 1 | withdrawn | Feb 11, 2014 | Virginia Commonwealth University | Due to no accrual. | Enrollment / accrual |
| NCT01486459 | A Feasibility Trial Using Lithium As A Neuroprotective Agent In Patients Undergoing…(TULIP) | N/A | terminated | Dec 6, 2011 | Barwon Health | Insufficient recruits | Enrollment / accrual |
| NCT01133262 | Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET)… | — | withdrawn | May 28, 2010 | Washington University School of Medicine | Feasibility/pilot study of 5 subjects registration not required | Other (stated, no rule matched) |
| NCT01591512 | A Prospective Longitudinal Collection of Subjects Diagnosed With Small Cell Lung Cancer | — | terminated | May 4, 2012 | Fujirebio Diagnostics, Inc. | Decision was made by Sponsor to stop the trial. | Other (stated, no rule matched) |
| NCT02033538 | Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell… | Phase 2 | withdrawn | Jan 10, 2014 | Zhejiang University | This clinical trial was closed due to slow recruitment of patients. | Enrollment / accrual |
| NCT02034968 | Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced… | Phase 2 | withdrawn | Jan 14, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT02041819 | Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of… | Phase 2 | withdrawn | Jan 22, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT00058214 | Perifosine in Treating Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | Did not meet interim stopping criteria for continuation to the second stage. | Other (stated, no rule matched) |
| NCT02011594 | Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma | Phase 2 | withdrawn | Dec 13, 2013 | Zhejiang University | There was no participants enrolled in this clinical trial. | Enrollment / accrual |
| NCT01720693 | Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy | Phase 2 | terminated | Nov 2, 2012 | University Health Network, Toronto | Low accrual | Enrollment / accrual |
| NCT01353794 | Study to Observe Safety and Efficacy of Nexavar in Treatment of Kidney Cancer(POWER-NEXT) | — | withdrawn | May 16, 2011 | Bayer | not stated | Not stated |
| NCT01989858 | ITACA-S2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach)(ITACA-S2) | Phase 3 | terminated | Nov 21, 2013 | Mario Negri Institute for Pharmacological Research | lack of clinical cases | Other (stated, no rule matched) |
| NCT01333852 | Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer(METTAX) | Phase 2 | terminated | Apr 12, 2011 | Lucas Vieira dos Santos | Low accrual | Enrollment / accrual |
| NCT01886287 | P:II Above-Label Octreotide-LAR With Insufficiently Controlled Carcinoid Syndrome | Phase 2 | terminated | Jun 25, 2013 | H. Lee Moffitt Cancer Center and Research Institute | Slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Sep 1, 2015source: clinicaltrials