Clinical trial · Interventional
Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in Pancreatic Head Cancer
Neoadjuvant Radiotherapy in Patients With Primary Resectable Adenocarcinoma of the Pancreatic Head Plus Adjuvant Chemotherapy: a Randomized Controlled Phase III Trial
NCT01419002CI-TRIAL-00018699Net-PacterminatedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): lack of recruitment
Summary
Brief summary (as posted)
Net-Pac investigates if radiation prior to surgical resection improves survival in patients with pancreatic head cancer without metastases.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Adenocarcinoma | Pancreatic Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| neoadjuvant RTx | Radiation | — | UNRESOLVED |
| Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Neoadjuvant RTx
- interventionNames
- Radiation: neoadjuvant RTx
- type
- ACTIVE_COMPARATOR
- label
- Surgery
- interventionNames
- Procedure: Surgery
Primary outcomes (1)
- measure
- Local recurrence free survival
- timeFrame
- At 12 months postoperative
Secondary outcomes (7)
- measure
- Percentage of surgical R0-resections in both groups
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed adenocarcinoma of the pancreatic head * Age ≥ 18 years * Signed informed consent * ECOG performance status of 0-2 Exclusion Criteria: * Curative resection is not feasible or presence of metastatic disease * Patients not eligible for surgery (ASA ≥ 4) * Participation in an other clinical trial * Unable or unwilling to sign the informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.