Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated NEURO-Endocrine Tumors

Inclusion Criteria:

* Digestive NET histopathologically proven, poorly-differentiated
* Inoperable/advanced NET (Tumor relapse inoperable or metastatic with no surgical indication).
* Tumor samples should be made available for analysis(diagnostic biopsy, surgical specimen)
* measurable disease defined by at least one lesion wich can be measured by at least one dimension :

  * equal or superior to 20 mm ( by conventional methods )
  * equal or superior to 10 mm (by spiral scan within 28 days before the beginning of the treatment)
* Performance status WHO ≤ 2.
* Adequate organ function :

  * hematology (absolute neutrophil count equal or superior to 1,5 x 10\*9/l , platelet equal or superior to 100 x 10\*9/l),
  * clearance of creatinine equal or superior to 60 ml/min),
  * AST/ALT ≤ 5 N, PAL ≤ 5 N, total bilirubin ≤ 2N.
* the selected women must be post-menopausal woman or surgically castrated or have to accept an effective contraception for the duration of the treatment and 3 month after.Women who are old enough to procreate must have a negative pregnancy test within the 72 hours of the beginning of the treatment.They must not be pregnant or to breastfeed.the selected men and theirs partners must be sterile or use an effective contraception for the duration of the treatment and 3 month after.

Exclusion Criteria:

* Hypersensitivity to sunitinib.
* Contraindication to sunitinib, including uncontrolled hypertension, medical history of cerebrovascular accident, unstable cardiac pathology despite optimal medical therapy (myocardial infarction within the 6 months prior to study drug administration, severe/unstable angina ), active hemorrhagic syndrome or concomitant treatment with anticoagulants.
* Any severe acute or chronic co-morbid that may compromise to comply with study participation: uncontrolled infection, symptomatic congestive heart failure, liver disturbance, chronic renal failure, active gastro-duodenal ulcer (nonexhaustive list).
* Known brain metastases.
* Diagnosis of any second malignancy within the last 3 years, except for basal cell or squamous cell skin cancer, or in situ carcinoma of the cervix uteri
* Current treatment on another clinical trial.
* Prior treatment with an investigational agent within 4 weeks.
* Prior treatment with intravenous biphosphonates