Clinical trial · Observational
Research Study in Patients With Advanced Ovarian Epithelial Cancer
A Pilot Study to Correlate DNA Sequence Copy Number Abnormalities With Outcome in Patients With Advanced Epithelial Ovarian Cancer
NCT00053235CI-TRIAL-00018090withdrawnClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research trial studies tissue samples from patients with ovarian cancer in the laboratory. Analyzing tissue samples from patients in the laboratory may help doctors learn more about cancer.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Serous Cystadenocarcinoma | Ovarian Serous Cystadenocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Ovarian Serous Surface Papillary Adenocarcinoma | Primary Peritoneal Serous Papillary Adenocarcinoma | ALIAS | 0.90 |
| Stage IIIA Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_BROADER | 0.78 |
| Stage IIIB Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_BROADER | 0.78 |
| Stage IIIC Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_BROADER | 0.78 |
| Stage IV Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comparative Genomic Hybridization | Genetic | — | UNRESOLVED |
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
| Polymerase Chain Reaction | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Ancillary-Correlative
- description
- Genomic DNA is isolated from OCT-embedded tissue and analyzed using comparative genomic hybridization. The chromosomal changes identified by this method are compared to those identified using the Taqman method, a quantitative genomic polymerase chain reaction analysis. Chromosome 8q is of specific interest. Other chromosomal changes may be detected in chromosomes 3q, 7q, 16q, and/or 17pter-q21.
- interventionNames
- Genetic: Comparative Genomic Hybridization
- Other: Laboratory Biomarker Analysis
- Genetic: Polymerase Chain Reaction
Primary outcomes (5)
- measure
- Association between above chromosomal changes and clinical characteristics
- timeFrame
- baseline
- measure
- Determination of whether a gain in chromosome 8q is predictive of worse overall survival in these patients
- timeFrame
- baseline
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria:
* Stage III or IV, high-grade (grade 2 or 3) ovarian cancers
* No borderline or low-grade (grade 1) tumors
* Tissue from predominately serous ovarian cancer only
* No clear cell, endometrioid, mucinous, transitional cell, or mixed without predominant serous component
* Tissue obtained during prior optimal or suboptimal cytoreductive surgery
* Must be enrolled on GOG-0136 and a GOG front-line paclitaxel/platinum chemotherapy trial
* Frozen tissue and hematoxylin-eosin stained section from the ovary obtained at initial surgery
* Performance status - GOG 0-2References
Publications (0)
Data not yet available
No reference posted for this study.