Clinical trial · Interventional
Clamped or Unclamped Surgery in Treating Patients With Kidney Cancer
Prospective Randomized Comparison of Clamped Versus Unclamped Partial Nephrectomy
NCT01547676CI-TRIAL-00017295terminatedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): P.I. decided to terminate study due to multiple unresolved issues
Summary
Brief summary (as posted)
This randomized pilot trial studies clamped or unclamped surgery in treating patients with kidney cancer. Unclamped surgery for kidney cancer may have fewer side effects
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Renal Cell Cancer | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| robot-assisted laparoscopic surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm A (unclamped partial nephrectomy)
- description
- Patients undergo unclamped partial nephrectomy. Some patients may undergo unclamped partial nephrectomy with controlled hypotension.
- interventionNames
- Procedure: robot-assisted laparoscopic surgery
- type
- ACTIVE_COMPARATOR
- label
- Arm B (clamped partial nephrectomy)
- description
- Patients undergo clamped partial nephrectomy.
- interventionNames
- Procedure: robot-assisted laparoscopic surgery
Primary outcomes (1)
- measure
- Change from baseline in renal function as measured by eGFR
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Solitary renal mass or solitary complex renal cyst Bosniak \>/= Grade 3 * Clinical stage T1a, T1b * Body Mass Index (BMI) \< 40 * Surgical candidate (preoperative cardiac and anesthesia clearance obtained) * Able to give informed consent * 24 hour urine collection complete and report obtained * MAG-3/DTPA scan completed and report obtained Exclusion Criteria: * Pregnancy * More than 1 renal mass or complex renal cyst Bosniak \>/= Grade 3 on ipsilateral kidney * Previous renal surgery on the ipsilateral kidney * Clinical Stage T2 or greater * BMI \> 40 * Contraindication to systemic hypotension: * Left Main Coronary Arterial Disease * Severe cardiac decompensation (ejection fraction \[EF\] \< 40%) * Prior history of cerebrovascular accident * Unable to consent * Unwilling or unable to potentially receive blood transfusion
References
Publications (0)
Data not yet available
No reference posted for this study.