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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00171925 | Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I | Phase 3 | terminated | Sep 15, 2005 | Novartis Pharmaceuticals | Recruitment in study could not be reached after 8 yrs of recruiting | Enrollment / accrual |
| NCT00933114 | Functional Imaging of Tumor and Normal Tissue(FITT) | — | terminated | Jul 7, 2009 | Duke University | Funding ceased | Funding |
| NCT01305239 | A Survey Of Clinical Practice Of Adjuvant Treatment Of Breast Cancer Using Exemestane…(ETAPE) | — | terminated | Feb 28, 2011 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00962572 | The Effects of Aggressive Patient Management on Cancer Therapy Management | — | withdrawn | Aug 20, 2009 | University of Mississippi Medical Center | Investigator decided not to pursue | Investigator |
| NCT00366106 | Alternative Schedule of Velcade/Dexamethasone Plus Doxil for Patients With Multiple… | Phase 2 | terminated | Aug 18, 2006 | Accelerated Community Oncology Research Network | Study was closed to enrollment when it became clear that enrollment was too slow to complete full… | Enrollment / accrual |
| NCT01045044 | Magnetic Resonance Imaging (MRI) of Tumor Response and Cognitive Impairment in Breast… | — | withdrawn | Jan 8, 2010 | Kettering Health Network | No participants enrolled | Enrollment / accrual |
| NCT01409226 | 3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women | N/A | withdrawn | Aug 4, 2011 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT00121186 | S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and… | Phase 2 | terminated | Jul 21, 2005 | SWOG Cancer Research Network | poor accrual | Enrollment / accrual |
| NCT00138229 | Cyclophosphamide and Fludarabine Followed By an Autologous Lymphocyte Infusion and… | Phase 2 | terminated | Aug 30, 2005 | National Institutes of Health Clinical Center (CC) | not stated | Not stated |
| NCT01075607 | Lymph Fluid and Blood Collection for Identification of Novel Biomarkers | — | terminated | Feb 25, 2010 | Indiana University | Halted prematurely due to lack of funding. | Funding |
| NCT00495625 | Sunitinib Malate (SUO11248) In Subjects W/ Metastatic And/Or Surgically Unresectable… | Phase 2 | terminated | Jul 3, 2007 | H. Lee Moffitt Cancer Center and Research Institute | not stated | Not stated |
| NCT00820287 | Identification of Predictive Markers for Testis Cancer in a Population of Men With High… | N/A | terminated | Jan 12, 2009 | Centre Hospitalier Universitaire de Nice | not stated | Not stated |
| NCT01445587 | A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma | Phase 2 | withdrawn | Oct 4, 2011 | GlaxoSmithKline | Based on the clinical activity, not safety data, of the AKT inhibitor, GSK has decided at this time… | Safety / toxicity |
| NCT00019409 | Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in… | Phase 3 | withdrawn | Feb 27, 2004 | National Institutes of Health Clinical Center (CC) | not stated | Not stated |
| NCT00480623 | A Phase I Trial of Satraplatin Plus Radiation Therapy for Prostate Cancer Patients With… | Phase 1 | terminated | May 31, 2007 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT00827099 | Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte… | Phase 2 | terminated | Jan 22, 2009 | Northside Hospital, Inc. | Unacceptable morbidity \& mortality | Other (stated, no rule matched) |
| NCT00503932 | Proton Therapy With Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Jul 19, 2007 | M.D. Anderson Cancer Center | No participant enrollment. | Enrollment / accrual |
| NCT01044225 | Effect of Radiation Therapy Plus Temozolomide Combined With Cilengitide or Cetuximab on… | Phase 2 | terminated | Jan 7, 2010 | Bart Neyns | Results of the phase III RTOG0525 trial made the manufacturer of cilengitide decide to end their… | Drug supply |
| NCT01353482 | A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With…(MESO-02) | Phase 1 / Phase 2 | withdrawn | May 13, 2011 | University College, London | UCL CTC were informed by Merck Sharp \& Dohme on 22.08.11 that support for the trial had been… | Other (stated, no rule matched) |
| NCT01337492 | Pilot Study Sorafenib as Bridge to Orthotopic Liver Transplantation (OLT) | Early Phase 1 | terminated | Apr 19, 2011 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00003929 | Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central… | Phase 2 | withdrawn | Jul 26, 2004 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00253461 | 11C Topotecan PET Imaging | Early Phase 1 | terminated | Nov 15, 2005 | Case Comprehensive Cancer Center | Drugs unavailable:unable to make radioactive topotecan | Other (stated, no rule matched) |
| NCT00402935 | Ovarian Damage in Young Premenopausal Women Undergoing Chemotherapy for Cancer | — | withdrawn | Nov 23, 2006 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00445757 | Stereotactic Radiation Therapy in Treating Patients With Kidney Tumors | Phase 1 | withdrawn | Mar 9, 2007 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00873002 | Panobinostat and Sorafenib in Treating Patients With Liver Cancer That is Metastatic… | Phase 1 | terminated | Apr 1, 2009 | Case Comprehensive Cancer Center | Dose Limiting Toxicity | Safety / toxicity |
| NCT01126450 | Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer | Phase 1 | terminated | May 19, 2010 | Case Comprehensive Cancer Center | low accrual,loss of funding and results from EU study showing drug ineffective. | Enrollment / accrual |
| NCT00389506 | Fludarabine and Cyclophosphamide Followed By LMB-2 Immunotoxin in Treating Patients With… | N/A | withdrawn | Oct 19, 2006 | National Institutes of Health Clinical Center (CC) | not stated | Not stated |
| NCT01052766 | Breathing Synchronized PET/CT Scans for the Detection of Malignant Lung & Liver Lesions… | N/A | terminated | Jan 20, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01109953 | Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold… | — | terminated | Apr 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT00657137 | APRiCOT-B: Study to Evaluate Apricoxib in Combination With Lapatinib and Capecitabine in…(APRiCOT-B) | Phase 2 | terminated | Apr 14, 2008 | Tragara Pharmaceuticals, Inc. | Slow accrual | Enrollment / accrual |
| NCT00739063 | Phase II Study of Erlotinib, an EGFR Inhibitor in Metastatic EGFR-positive 'Triple… | Phase 2 | terminated | Aug 21, 2008 | M.D. Anderson Cancer Center | Poor Accrual | Enrollment / accrual |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer… | Phase 2 | terminated | Apr 22, 2011 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00137683 | Colorectal Cancer Control in Appalachian Churches | Phase 2 / Phase 3 | withdrawn | Aug 30, 2005 | Centers for Disease Control and Prevention | not stated | Not stated |
| NCT00453635 | Study With Docetaxel, Carboplatin and Herceptin Versus Vinorelbine and Herceptin in HER-2… | Phase 2 | terminated | Mar 29, 2007 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT01066468 | Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and… | Phase 1 | terminated | Feb 10, 2010 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00892801 | Everolimus and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastasis… | Phase 1 | terminated | May 5, 2009 | Vanderbilt-Ingram Cancer Center | Terminated due to low accrual. Study was closed to accrual prematurely and did not continue on to… | Enrollment / accrual |
| NCT00003824 | S9809, Ciprofloxacin Compared With Cephalexin in Treating Patients With Bladder Cancer | Phase 3 | terminated | Apr 14, 2004 | SWOG Cancer Research Network | Permanently Closed Due to Poor Accrual | Enrollment / accrual |
| NCT00611650 | Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia | Phase 2 | terminated | Feb 11, 2008 | British Columbia Cancer Agency | Slow recruitment | Enrollment / accrual |
| NCT00485563 | A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive… | Phase 2 | terminated | Jun 13, 2007 | Endocyte | Changes in treatment paradigm resulted in a lower than expected rate of accrual. | Enrollment / accrual |
| NCT01546337 | Search for Predictive Markers of Efficacy of ESAs in Patients With Non-myeloid…(EPO) | — | terminated | Mar 7, 2012 | Rennes University Hospital | not stated | Not stated |
| NCT00003640 | Transurethral Resection and Combination Chemotherapy in Treating Patients With Stage II… | Phase 2 | terminated | May 20, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00003642 | Radiation Therapy and Chemotherapy Following Surgery in Treating Patients With Stage II… | Phase 2 | terminated | Apr 9, 2004 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00110721 | GM-CT-01 Plus 5-Fluorouracil as Third- or Fourth-Line Therapy for Metastatic Colorectal… | Phase 2 | terminated | May 13, 2005 | Galectin Therapeutics Inc. | Study protocol amended to a new treatment regimen: study DAVFU-006. | Other (stated, no rule matched) |
| NCT00998101 | Carboplatin, Ixabepilone, and Cetuximab in Patients With Stage III or Stage IV Non-Small… | Phase 2 | withdrawn | Oct 20, 2009 | UNC Lineberger Comprehensive Cancer Center | Study was withdrawn due issuses related to the science | Other (stated, no rule matched) |
| NCT00773318 | SPECT-CT Guided Lymphatic Mapping and Sentinel Lymphadenectomy (LM/SL) in Prostate Cancer | N/A | terminated | Oct 16, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 patient has been enrolled. No complications reported. The research team decided to terminate the… | Enrollment / accrual |
| NCT00804544 | 99mTc-MIBI SPECT/CT in Breast Malignancy | N/A | terminated | Dec 9, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 4 patients have been enrolled into the pilot study. No complications reported. Another clinical… | Enrollment / accrual |
| NCT00429078 | Trial of 2nd Generation Anti-CEA Designer T Cells in Gastric Cancer | Phase 1 | withdrawn | Jan 31, 2007 | Roger Williams Medical Center | low accrual | Enrollment / accrual |
| NCT00532987 | Assessment of Health Related Quality of Life in Patients Treated for Rectal Cancer | — | terminated | Sep 21, 2007 | Stanford University | not stated | Not stated |
| NCT00831493 | Vorinostat Plus Radiation Therapy in Pancreatic Cancer | Phase 1 / Phase 2 | terminated | Jan 29, 2009 | M.D. Anderson Cancer Center | Slow Accrual. | Enrollment / accrual |
| NCT00955890 | Dexrazoxane as a Protective Agent in Anthracycline Treated Breast Cancer(cardioprotec) | Phase 2 | terminated | Aug 10, 2009 | Fudan University | Enrolled too slow | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Apr 11, 2012source: clinicaltrials