Clinical trial · Interventional
Trial of 2nd Generation Anti-CEA Designer T Cells in Gastric Cancer
Phase I Trial of 2nd Generation Anti-CEA Designer T Cells in Gastric Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): low accrual
Summary
Brief summary (as posted)
This study proposes to determine the safety and tolerability of 2nd generation designer T cells in patients with gastric cancer.Designer T cells are prepared by removing white blood cells from the participant, and then modifying these cells so that they recognize tumor antigen(CEA). These modified cells are then re infused back into the participant so that they can attack and kill tumor cells.Eligibility for this study is diagnosis of carcinoma of the stomach with failure to respond to standard curative therapy. Tumors must express CEA as demonstrated by elevated serum CEA \>10ng/ml and be measurable radiologically or by physical exam.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 2nd Generation Designer T Cells | Genetic | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * CEA expressing Gastric Cancer/GE Junction (\>10ng/ml) * Must have measurable disease radiologically or by physical exam * Must have failed potentially curative standard therapy * Must be 18 years of age or older * No serious concomitant disease Exclusion Criteria: * Prior investigational treatment * Requiring systemic steroids * Serious medical conditions * Concurrent malignancies
References
Publications (0)
Data not yet available