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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,647 stopped studies mapped to Malignant Lung Neoplasm and descendants · 90% state a reason
Over the 1,647 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02261805 | A Phase I/II Study of Ganetespib in Combination With Doxorubicin | Phase 1 / Phase 2 | terminated | Oct 10, 2014 | Georgetown University | Company terminated drug support | Sponsor / business decision |
| NCT00901537 | Azacitidine and Cisplatin in Patients With Advanced Lung or Head and Neck Cancer | Phase 1 | terminated | May 14, 2009 | Loma Linda University | Sponsor terminated due to no enrollments within last 4 months. | Enrollment / accrual |
| NCT01188486 | Pulmonary Interstitial Lymphography in Early Stage Lung Cancer | N/A | terminated | Aug 25, 2010 | Stanford University | Business decision | Sponsor / business decision |
| NCT03048136 | A Safety Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced…(CheckMate 955) | Phase 3 | withdrawn | Feb 9, 2017 | Bristol-Myers Squibb | Business objective has changed | Sponsor / business decision |
| NCT00859742 | Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS-TBNA) for… | N/A | withdrawn | Mar 11, 2009 | National Cancer Center, Korea | not stated | Not stated |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT00281021 | Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer | Phase 2 | terminated | Jan 24, 2006 | University of Louisville | Interim analysis revealed that only 1 patient had a partial response. | Efficacy / futility |
| NCT03004105 | MEDI4736 With Selumetinib for KRAS Mutant Non-Small Cell Lung Cancer (NSCLC) | Phase 2 | withdrawn | Dec 28, 2016 | M.D. Anderson Cancer Center | Inadequate funding | Funding |
| NCT00449657 | Phase II Trial of Pulsed Taxol With Concurrent Thoracic Radiotherapy, & Adjuvant Chemo in… | Phase 2 | terminated | Mar 20, 2007 | Leo W. Jenkins Cancer Center | Poor accrual, change in standard of care. | Enrollment / accrual |
| NCT00096265 | Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib… | Phase 3 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00077064 | Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small… | Phase 2 | terminated | Feb 11, 2004 | Radiation Therapy Oncology Group | Due to unmet accrual/randomization goals | Enrollment / accrual |
| NCT01859338 | Soft Tissue Detection on MRI, Cone Beam CT and Fan Beam CT and Integration of Functional… | — | terminated | May 21, 2013 | Virginia Commonwealth University | Slow accrual | Enrollment / accrual |
| NCT00265200 | Using TRAP to Evaluate the Effect of Zometa on Bone Metastasis Due to Lung Cancer | Phase 2 | terminated | Dec 14, 2005 | University of Louisville | funding discontinued by sponsor | Funding |
| NCT00268151 | Oxaliplatin in Combination With Capecitabine and Concurrent Radiation Therapy in… | Phase 1 | terminated | Dec 22, 2005 | University of Louisville | Study was terminated due to lack of funding. | Funding |
| NCT01300299 | STEREOtactic Radiation and Chemotherapy in Lung Cancer (STEREO)(STEREO) | N/A | withdrawn | Feb 21, 2011 | University of Louisville | Unable to enroll | Enrollment / accrual |
| NCT01426620 | Standard Chemotherapy With Blueberry Powder in Non-Small Cell Lung Cancer(BIT-2) | Phase 2 | terminated | Aug 31, 2011 | University of Louisville | slow accrual | Enrollment / accrual |
| NCT02491775 | Afatinib Genomic Landscape | — | terminated | Jul 8, 2015 | Washington University School of Medicine | Changes in treatment plan affecting drug therapy choices | Other (stated, no rule matched) |
| NCT02554591 | Genomic Landscape of Ceritinib | — | terminated | Sep 18, 2015 | Washington University School of Medicine | Changes in treatment plans affecting drug therapy choices | Other (stated, no rule matched) |
| NCT02653612 | Intraoperative Imaging of Pulmonary Adenocarcinoma | Phase 1 | withdrawn | Jan 12, 2016 | VA Office of Research and Development | This study has been terminated, without having enrolled any participants | Enrollment / accrual |
| NCT02590003 | Single Agent Versus Combination Chemotherapy to Treat High-risk Elderly With Non-small… | Phase 2 | terminated | Oct 28, 2015 | Yale University | Trial was stopped after non-response to treatment. | Other (stated, no rule matched) |
| NCT02342353 | Pacritinib in Patients With Endothelial Growth Factor (EGFR) Mutant Non-small Cell Lung… | Phase 1 | terminated | Jan 19, 2015 | Washington University School of Medicine | Drug shortage | Other (stated, no rule matched) |
| NCT01710293 | Intervention Protocol for Automated Point-of-Care Surveillance of Outpatient Delays in…(PACT CREATE 3) | N/A | withdrawn | Oct 19, 2012 | VA Office of Research and Development | Unable to obtain data needed to run the RCT; project never began recruitment | Enrollment / accrual |
| NCT01090830 | Safety and Efficacy of Belinostat When Used With Standard of Care Chemotherapy for…(HCH003) | Phase 1 / Phase 2 | terminated | Mar 23, 2010 | Holy Cross Hospital, Florida | Principal Investigator has left institution. IND withdrawn. | Investigator |
| NCT00588263 | Anonymous Testing of Pathology Specimens for BRCA Mutations in Ashkenazi Jewish… | — | withdrawn | Jan 8, 2008 | Memorial Sloan Kettering Cancer Center | Data from MSK-IMPACT is sufficient for relevant analyses going forward | Other (stated, no rule matched) |
| NCT02119650 | Ruxolitinib in Combination With Pemetrexed/Cisplatin in Non Small Cell Lung Cancer | Phase 2 | terminated | Apr 22, 2014 | Incyte Corporation | The study was terminated as other related studies of ruxolitinib did not provide sufficient… | Efficacy / futility |
| NCT03053297 | Observational Study of Patients With Locally Advanced or Metastatic NSCLC (Non-Small Cell…(PANORAMA) | — | terminated | Feb 15, 2017 | AstraZeneca | Cancelled due to changes in the scientific landscape. Decision was made after thorough evaluation… | Other (stated, no rule matched) |
| NCT02393209 | Docetaxel With or Without TAK-117 (MLN1117) in Participants With Locally Advanced or… | Phase 1 / Phase 2 | terminated | Mar 19, 2015 | Millennium Pharmaceuticals, Inc. | Lack of efficacy in combination. | Efficacy / futility |
| NCT00681512 | The Effect of Berries on Lung Cancer Tumors | N/A | terminated | May 21, 2008 | University of Louisville | slow accrual | Enrollment / accrual |
| NCT00003497 | Antineoplaston Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT03087305 | Incidence of SCLN Metastasis in Patients Referred for EBUS-TBNA | — | withdrawn | Mar 22, 2017 | University of Minnesota | low enrollment rate | Enrollment / accrual |
| NCT01652456 | Alcohol and Tobacco Consumption in Patients With Head and Neck Cancer : Interest of an… | N/A | withdrawn | Jul 30, 2012 | Centre Oscar Lambret | not stated | Not stated |
| NCT02134015 | Study of Patritumab in Combination With Erlotinib in Subjects With Locally Advanced or…(HER3-Lung) | Phase 3 | terminated | May 8, 2014 | Daiichi Sankyo | Pre-defined criteria for continuation were not reached | Other (stated, no rule matched) |
| NCT02166658 | A Study of Cabazitaxel for Patients With Breast or Lung Cancer and Recurrent or…(CaBaMet) | Phase 2 | terminated | Jun 18, 2014 | AIO-Studien-gGmbH | After a recruitment of more than 2 years, only 8 patients have been registered. | Enrollment / accrual |
| NCT02326285 | Induction Therapy With Intercalated Tyrosine Kinase Inhibitor (TKI) and Chemotherapy in…(NeoIntercal) | Phase 2 / Phase 3 | terminated | Dec 29, 2014 | AIO-Studien-gGmbH | Due to low patient enrollment was stopped. Only one patient could be enrolled. 37 patients were… | Enrollment / accrual |
| NCT01237678 | A Study of IMGN901 for Patients With Advanced Solid Tumors and Extensive Stage Small Cell… | Phase 1 / Phase 2 | terminated | Nov 9, 2010 | ImmunoGen, Inc. | Study was stopped early due to lack of efficacy signal and safety concerns | Safety / toxicity |
| NCT01574222 | A Vaccine Trial for Patients With Stage IIIB, IV, or Recurrent Non-Small Cell Lung Cancer(VTNSCLC) | Phase 1 | terminated | Apr 10, 2012 | VA Office of Research and Development | Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome… | Other (stated, no rule matched) |
| NCT02018523 | Lenalidomide Maintenance Therapy in Stage IIIB/IV Non-small Cell Lung Cancer | Phase 1 | terminated | Dec 23, 2013 | Jun Zhang | Study did not enroll enough subjects to make a statistically sound conclusion. | Enrollment / accrual |
| NCT02919462 | Open-label, Multicenter, Randomized Phase II Trial of Treatment With Cisplatin and…(HighTySy) | Phase 2 | terminated | Sep 29, 2016 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | low recruitement rate | Enrollment / accrual |
| NCT00470548 | Abraxane and Alimta in Advanced Solid Tumors | Phase 1 / Phase 2 | terminated | May 7, 2007 | University of California, Davis | Practice patterns with pemetrexed have evolved. | Other (stated, no rule matched) |
| NCT00807755 | Everolimus, Carboplatin, and Etoposide in Treating Patients With Small Cell Lung Cancer… | Phase 1 | terminated | Dec 12, 2008 | University of California, Davis | Number of known toxicities observed despite a treatment-naïve population | Safety / toxicity |
| NCT01261299 | Clinical Study of Microdosing Carboplatin in Lung or Bladder Cancer | Early Phase 1 | terminated | Dec 16, 2010 | University of California, Davis | Contract ended | Other (stated, no rule matched) |
| NCT01419587 | Ketogenic Diet With Chemoradiation for Lung Cancer (KETOLUNG) | N/A | terminated | Aug 18, 2011 | University of Iowa | Poor accrual and compliance | Enrollment / accrual |
| NCT00369070 | A Phase 2 Trial of AMG 706 or Bevacizumab in Combination With Chemo for Advanced NSCLC | Phase 2 | terminated | Aug 29, 2006 | Amgen | not stated | Not stated |
| NCT00281827 | Carboplatin, Gemcitabine, and Thalidomide in Patients Undergoing Surgery for Stage II or… | Phase 2 | terminated | Jan 25, 2006 | Masonic Cancer Center, University of Minnesota | Due to drug unavailability | Other (stated, no rule matched) |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT02168036 | Study of Biologic Materials From the Mediastinal Lymph Nodes From Patients With Lung… | — | terminated | Jun 19, 2014 | Weill Medical College of Cornell University | Study was terminated due to lack of funding. | Funding |
| NCT01797471 | Safety of LEAD Radiotherapy Plus Chemoradiation in Patients With Bulky Stage III… | N/A | terminated | Feb 22, 2013 | University of Miami | not stated | Not stated |
| NCT02336061 | Evaluation of Gender Differences on the Psychosocial and Economic Impact in Patients With…(IMPULSO) | — | terminated | Jan 12, 2015 | Asociación para la Investigación del Cáncer de Pulmón en Mujeres | Sponsor decision due to the low recruitment rate | Enrollment / accrual |
| NCT00769990 | Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone… | Phase 1 / Phase 2 | withdrawn | Oct 9, 2008 | Masonic Cancer Center, University of Minnesota | No patient accrual. | Enrollment / accrual |
| NCT00794547 | Phase I/II Calcitriol in Lung Cancer | Phase 1 / Phase 2 | terminated | Nov 20, 2008 | University of Michigan Rogel Cancer Center | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 23, 2018source: clinicaltrials