Clinical trial · Interventional
Pulmonary Interstitial Lymphography in Early Stage Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Business decision
Summary
Brief summary (as posted)
The stereotactic body radiation therapy (SBRT) procedure is an emerging alternative to the standard treatment for early stage non-small cell lung cancer (NSCLC), typically lobectomy with lymphadenectomy. This procedure (lobectomy) does not fulfill the medical need as many patients are poor operative candidates or decline surgery. This study assesses the feasibility of stereotactic body radiation therapy (SBRT) as a tool to produce therapeutically useful computed tomography (CT) scans, using standard water-soluble iodinated compounds as the contrast agents.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lung Cancer Non-Small Cell Cancer (NSCLC) | Lung Non-Small Cell Carcinoma | ALIAS | 0.85 |
| Lung Cancer Small Cell Lung Cancer (SCLC) | Lung Small Cell Carcinoma | ALIAS | 0.85 |
| Mesothelioma | Malignant Mesothelioma | CURATED_EXACT | 0.92 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Computed Tomography (CT) | Radiation | — | UNRESOLVED |
| Cyberknife | Device | — | UNRESOLVED |
| Iodixanol | Drug | — | UNRESOLVED |
| Iohexol | Drug | — | UNRESOLVED |
| Stereotactic Body Radiation Therapy (SBRT) | Radiation | — | UNRESOLVED |
| Trilogy | Device | — | UNRESOLVED |
| True Beam | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- pulmonary interstitial lymphography
- description
- stereotactic body radiation therapy \& pulmonary interstitial lymphography
- interventionNames
- Radiation: Stereotactic Body Radiation Therapy (SBRT)
- Radiation: Computed Tomography (CT)
- Device: Cyberknife
- Device: Trilogy
- Device: True Beam
- Drug: Iohexol
- Drug: Iodixanol
Primary outcomes (1)
- measure
- - Feasibility and safety of identification of primary nodal drainage for purpose of radiation therapy targeting
- timeFrame
- 15 months
Secondary outcomes (1)
- measure
- - Feasibility of incorporating primary nodal drainage into radiation therapy planning process
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
INCLUSION CRITERIA
* Either:
* Established primary lung cancer/ cancer metastatic to lung, OR
* Lesion suspicious for malignancy in lung, according to the following criteria:
* Histopathologically confirmed lung cancer or cancer metastatic to lung, OR
* Plan for biopsy of suspicious lung mass based on imaging (growth on serial CT scan or nodule/mass with focal hypermetabolism on FDG-PET scan), OR
* Known metastatic cancer, with metastases to the lung based on imaging
* Age \> 18 years old
* Eastern Clinical Oncology Group (ECOG) performance status 0, 1 or 2 (Appendix IV)
* No prior surgery, chemotherapy, or radiation for the current lung tumor
EXCLUSION CRITERIA
* Prior radiotherapy to thorax
* Iodine allergy
* Contraindication to receiving radiotherapy, unless undergoing surgery
* PregnantReferences
Publications (0)
Data not yet available