Ketogenic Diet With Chemoradiation for Lung Cancer (KETOLUNG)

Inclusion Criteria:

* Histologically or cytologically documented NSCLC.
* Candidate for primary chemoradiation as decided by both medical and radiation oncology.
* Cancer should be staged via AJCC as IIIA or IIIB.
* Stage IV patients are considered provided they have a single non-CNS metastasis (that is amenable to treatment with radiation therapy).
* Age ≥ 18 years
* ECOG performance status 0-2 (Karnofsky \> 50%, see Appendix A).
* Hypertensive medication should be initiated or increased for optimal blood pressure control according to standard public health guidelines prior to starting the ketogenic diet.
* Patients must have normal organ and marrow function as defined below:
* leukocytes ≥ 3,000/mm3
* absolute neutrophil count ≥ 1,500/mm3
* platelets ≥ 100,000/mm3
* total bilirubin \< 1.5 mg/dl
* Hgb A1C \< or = to 8%
* AST(SGOT) \< or = to 2 X institutional upper limit of normal
* creatinine \< 1.5 X institutional upper limit of normal OR creatinine clearance ≥ 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal.
* Not pregnant. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* Life expectancy of 3 or less months.
* Prior thoracic radiotherapy.
* Prior therapy, with the intent to treat, the current diagnosis of lung cancer.
* Known G6PD (glucose-6-phosphate dehydrogenase) deficiency.
* Systemic corticosteroids for any reason (inhaled corticosteroids are allowed).
* Other investigational agents/therapy with the intention to treat the disease under study (observational or imaging trials are acceptable).
* Uncontrolled diabetes defined as a hemoglobin A1C level \> 8% (therapeutic action is indicated at greater than 8%).
* Diabetes is not exclusionary provided the patient is not maintained with either oral medications or insulin.
* Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements as determined by study team members.
* Pregnant or lactating women: The risks of radiation and chemotherapy to a fetus are well documented.

Female and male patients of all ethnic groups will be eligible for treatment in these protocols.