Clinical trial · Interventional
Oxaliplatin in Combination With Capecitabine and Concurrent Radiation Therapy in Non-Small Cell Lung Cancer
Phase I Study of Oxaliplatin (Eloxatin) and Capecitabine (Xeloda) and Concurrent Radiation Therapy (XELOX-RT) in Non-Small Cell Lung Cancer
NCT00268151CI-TRIAL-00031907terminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Study was terminated due to lack of funding.
Summary
Brief summary (as posted)
The purpose of this study is to determine the most suitable dose of Oxaliplatin that can be safely given in combination with a low fixed dose of Capecitabine and a limited volume of radiation in patients with non-small cell lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Non-Small Cell Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Capecitabine | Drug | Capecitabine | ALIAS |
| Oxaliplatin | Drug | Oxaliplatin | ALIAS |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * histologically proven non-small cell lung cancer * inoperable Stage III A or B NSCLC * must have measurable disease by RECIST criteria * no more than one prior chemotherapy for advanced disease * ECOG Performance Status of 0, 1, or 2 * must be able to swallow pills or have a working gastric feeding tube and no evidence of malabsorption * negative serum beta-HCG test and under active contraception (for females of childbearing potential) * no known allergies to any of the study drugs * willingness to sign an informed consent Exclusion Criteria: * women who are pregnant or breastfeeding * ANC of less than 1500/mm3 * platelet count of less than 100,000/mm3 * estimated creatinine clearance of less than 50 cc/min (as measured by the Cockcroft-Gault equation) * bilirubin of less than 2mg/dl * SGPT of greater than 2x nl * peripheral neuropathy of Grade 2 or higher * more than one previous chemotherapy and previous radiation therapy to the chest * a history of CHF/MI or other significant cardiac history within the last six months
References
Publications (0)
Data not yet available
No reference posted for this study.